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Conversional studies towards taxoids from C(19)-diterpenoid alkaloids by the BAC sequence
- Source :
- Journal of Asian natural products research. 12(11)
- Publication Year :
- 2010
-
Abstract
- The conversional synthesis of taxoids by the BAC sequence from the C(19)-diterpenoid alkaloids, 14-acetyltalatisamine (1), yunaconitine (12), and 14-acetylchasmanine (19), was designed and explored. Two aconane-type diterpenes 17 and 28, the advanced intermediates for our conversional synthesis, were synthesized. The key steps include the rupture of the C(7)-C(17) bond, the formation of imine, and the denitrogenation.
- Subjects :
- Stereochemistry
Aconitine
Imine
Pharmaceutical Science
Sequence (biology)
Chemical synthesis
Analytical Chemistry
chemistry.chemical_compound
Alkaloids
Drug Discovery
Organic chemistry
Nuclear Magnetic Resonance, Biomolecular
Pharmacology
Molecular Structure
Chemistry
Alkaloid
Organic Chemistry
General Medicine
Terpenoid
Yunaconitine
Complementary and alternative medicine
Talatisamine
Molecular Medicine
Taxoids
Diterpene
Diterpenes
Drugs, Chinese Herbal
Subjects
Details
- ISSN :
- 14772213
- Volume :
- 12
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Journal of Asian natural products research
- Accession number :
- edsair.doi.dedup.....5e225ad06e3a2a556faf29c682b7e5da