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Clinical and Neurophysiological Studies of Aldose Reductase Inhibitor Ponalrestat in Chronic Symptomatic Diabetic Peripheral Neuropathy
- Source :
- Diabetes. 40:129-133
- Publication Year :
- 1991
- Publisher :
- American Diabetes Association, 1991.
-
Abstract
- Increased flux through the polyol pathway mediated by the enzyme aldose reductase may be associated with the development of diabetic neuropathy. Fifty-four diabetic patients (median age 56 yr, range 25-65 yr) with chronic neuropathic symptoms were randomly allocated to placebo or aldose reductase inhibition (300 or 600 mg ponalrestat ICI 128436) groups for 24 wk. Patients with vibration perception thresholds (VPTs) greater than 35 V at the great toe or thermal difference thresholds (TTs) greater than 10 degrees C on the dorsum of the foot were excluded from the trial. No significant changes were observed in symptoms of pain, numbness, or paresthesia between ponalrestat and placebo groups, and there were no improvements in VPT or TT at several sites. Posterior tibial nerve conduction velocity changed from 35.3 +/- 4.9 m/s at baseline to 33.4 +/- 4.0 m/s at 24 wk (NS) with placebo compared with 37.6 +/- 5.6 vs. 37.2 +/- 8.7 m/s (NS) with 300 mg ponalrestat and 34.5 +/- 6.1 vs. 36.2 +/- 6.8 m/s (NS) with 600 mg ponalrestat. Further studies are indicated with intervention at an earlier stage in the evolution of neuropathy and for longer periods.
- Subjects :
- medicine.medical_specialty
Diabetic neuropathy
Endocrinology, Diabetes and Metabolism
Urology
Placebo
Nerve conduction velocity
Vibration perception
Polyol pathway
Diabetic Neuropathies
Aldehyde Reductase
Internal medicine
Internal Medicine
medicine
Humans
Neurons, Afferent
Aldose reductase
business.industry
Middle Aged
medicine.disease
Aldose reductase inhibitor
Median Nerve
Peripheral neuropathy
Endocrinology
Sensory Thresholds
Phthalazines
Tibial Nerve
business
medicine.drug
Subjects
Details
- ISSN :
- 1939327X and 00121797
- Volume :
- 40
- Database :
- OpenAIRE
- Journal :
- Diabetes
- Accession number :
- edsair.doi.dedup.....5e2243bcd3dd86f4f69bfb5893cd831b