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Innate response activator B cells protect against microbial sepsis
- Source :
- Science (New York, N.Y.). 335(6068)
- Publication Year :
- 2012
-
Abstract
- Immune Sentinels A classic paradigm in immunology holds that the immune response occurs in two waves: Rapidly responding cells of the innate immune system help to contain the invading pathogen and alert lymphocytes. These cells of the adaptive immune system then help to clear the infection and go on to form long-lasting memory. However, some specialized populations of lymphocytes can also respond quickly to an infection and carry out functions that overlap with the innate immune system. Now, Rauch et al. (p. 597 , published online 12 January) describe one such cell type—innate response activator (IRA) B cells. IRA B cells recognize bacterial liposaccharide through Toll-like receptor 4 and, in response, produce the cytokine GM-CSF, which activates other innate immune cells. Deletion of IRA B cells in mice impaired their ability to clear a bacterial infection and promoted septic shock.
- Subjects :
- Lipopolysaccharides
Population
B-Lymphocyte Subsets
Parabiosis
Cell Separation
Biology
Integrin alpha4beta1
Peritonitis
Lymphocyte Activation
Article
Microbiology
Immunophenotyping
Classical complement pathway
Mice
Sepsis
medicine
Animals
Cell Lineage
education
B cell
Escherichia coli Infections
education.field_of_study
Multidisciplinary
Innate immune system
Innate lymphoid cell
CCL18
Granulocyte-Macrophage Colony-Stimulating Factor
Acquired immune system
medicine.disease
Flow Cytometry
Shock, Septic
Immunity, Innate
Lymphocyte Function-Associated Antigen-1
Mice, Inbred C57BL
Toll-Like Receptor 4
medicine.anatomical_structure
Immunoglobulin M
Immunology
Female
Cytokine storm
Spleen
Subjects
Details
- ISSN :
- 10959203
- Volume :
- 335
- Issue :
- 6068
- Database :
- OpenAIRE
- Journal :
- Science (New York, N.Y.)
- Accession number :
- edsair.doi.dedup.....5e17b332ca55e132ce19c8e52722bd24