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Comparative nasal airflow with loratadine-pseudoephedrine and fluticasone nasal spray for allergic rhinitis
- Source :
- Annals of Allergy, Asthma & Immunology. 127:342-348.e2
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- BACKGROUND Although it is known that oral antihistamine-pseudoephedrine combination tablets have a faster onset than intranasal corticosteroid sprays in the treatment of allergic rhinitis after the first dose, the magnitude of change has not been measured in a comparative manner. Furthermore, the sensation of sprayed liquid in the nose may lead patients to mistakenly believe that intranasal steroid sprays work instantly. OBJECTIVE To evaluate, numerically, nasal airflow changes provided by a single dose of loratadine-pseudoephedrine tablet (LP) and fluticasone propionate nasal spray (FP) in participants experiencing allergic rhinitis symptoms, including nasal congestion. METHODS This single-center, double-blinded, placebo-controlled, crossover study evaluated objective nasal airflow changes in patients with a documented sensitivity to ragweed pollen. Participants were randomized to receive 1 of 4 treatment sequences, and their peak nasal inspiratory flow (PNIF) was measured in a span of 4 hours after pollen exposure in an environmental exposure unit. RESULTS Average change in PNIF was 31% with LP in the course of the study, significantly greater than with placebo and FP (12% and 15%, respectively; P < .001). Nevertheless, FP did not produce a significant change compared with its placebo. At hour one post-dose, LP had a clinically significant 31% increase in PNIF, whereas FP only yielded an 8.6% increase (P < .001). Measurable nasal airflow improvements are associated with the opening of nasal passages, allowing congested patients to breathe more freely. CONCLUSION A single dose of LP quickly and significantly (P < .001) improved nasal airflow after ragweed pollen challenge in an environmental exposure unit. Comparatively, FP did not display this same benefit. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT03443843.
- Subjects :
- Adult
Male
Pulmonary and Respiratory Medicine
medicine.medical_treatment
Immunology
Nasal congestion
Fluticasone propionate
Young Adult
03 medical and health sciences
0302 clinical medicine
Double-Blind Method
Anti-Allergic Agents
otorhinolaryngologic diseases
Humans
Immunology and Allergy
Medicine
030212 general & internal medicine
Administration, Intranasal
Nose
Fluticasone
Cross-Over Studies
business.industry
Nasal Sprays
Environmental exposure
Loratadine
Middle Aged
Pseudoephedrine
Rhinitis, Allergic
Drug Combinations
Nasal Decongestants
medicine.anatomical_structure
030228 respiratory system
Nasal spray
Anesthesia
Peak Nasal Inspiratory Flow
Respiratory Physiological Phenomena
Female
Nasal administration
Nasal Cavity
medicine.symptom
business
Tablets
medicine.drug
Subjects
Details
- ISSN :
- 10811206
- Volume :
- 127
- Database :
- OpenAIRE
- Journal :
- Annals of Allergy, Asthma & Immunology
- Accession number :
- edsair.doi.dedup.....5e06889380bb125d54413369b519724e