A convenient synthesis of 4(5)-(hetero)aryl-1H-imidazoles via microwave-assisted Suzuki–Miyaura cross-coupling reaction

Authors :: Sophie Vichier-Guerre
Sylvie Pochet
Laurence Dugué
Chimie et Biocatalyse
Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris]
This work was financially supported by the Direction des Applications de la Recherche et des Relations Industrielles (DARRI no. 08-183), Institut Pasteur and CNRS.
Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)
Source :: Tetrahedron Letters, Tetrahedron Letters, Elsevier, 2014, 55 (46), pp.6347-6350. ⟨10.1016/j.tetlet.2014.09.104⟩, Tetrahedron Letters, 2014, 55 (46), pp.6347-6350. ⟨10.1016/j.tetlet.2014.09.104⟩
Publication Year :: 2014
Publisher :: HAL CCSD, 2014.
Abstract: International audience; A simple and rapid access to a variety of 4(5)-arylated imidazoles via palladium-catalyzed Suzuki–Miyaura cross-coupling reaction is described. Coupling parameters were screened for efficient C-4 arylation of N-unprotected 4-iodoimidazole with a broad range of boronic acids under microwave irradiation. Twenty-one imidazole derivatives were synthesized in modest to excellent yields in short reaction times.

Language :: English
ISSN :: 00404039 and 18733581
Database :: OpenAIRE
Journal :: Tetrahedron Letters, Tetrahedron Letters, Elsevier, 2014, 55 (46), pp.6347-6350. ⟨10.1016/j.tetlet.2014.09.104⟩, Tetrahedron Letters, 2014, 55 (46), pp.6347-6350. ⟨10.1016/j.tetlet.2014.09.104⟩
Accession number :: edsair.doi.dedup.....5dfcfc8bf257ac7d21aec38eff9e68eb
Full Text :: https://doi.org/10.1016/j.tetlet.2014.09.104⟩

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