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Risks associated with premature ovarian failure in Han Chinese women
- Source :
- Reproductive BioMedicine Online. 30:401-407
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- In this retrospective study, the relationship between demographic characteristics, past medical history, general lifestyle habits and susceptibility of premature ovarian failure (POF) in Han Chinese population was investigated. Five hundred and fifty-three patients with POF and 400 women with normal ovarian function were recruited. A questionnaire was designed to gather information from responders. Logistic regression was carried out to calculate odds ratios (OR), 95% confidence intervals (95% CI) and P-values. History of pelvic surgery, mumps, having relatives with menstrual abnormalities and exposure to chemical agents were significantly associated with increased risk of POF (OR 5.53 [2.15 to 14.23]; 3.26 [2.38 to 4.47]; 28.12 [8.84 to 89.46]; 4.47 [2.09 to 9.58]). Vegetarian diet, tea and mineral water consumption reduced the risk of POF (OR 0.27 [0.19 to 0.37]; 0.04 [0.03 to 0.07]; 0.63 [0.47 to 0.85], respectively). Heredity, pelvic surgery, mumps and exposure to chemical agents were identified as risk factors for POF, whereas vegetarian diet, tea consumption and mineral water drinking were protective. Therefore, genetic consultation could help those women whose relatives manifested an early or premature menopause to avoid the consequences of possible premature ovarian function cessation. Avoidance of exposure to endocrine disrupters and flavonoids intake should be considered.
- Subjects :
- Adult
China
medicine.medical_specialty
Primary Ovarian Insufficiency
Logistic regression
Risk Factors
medicine
Humans
Family
Medical history
Life Style
Mumps
Premature Menopause
Retrospective Studies
Gynecology
Past medical history
Obstetrics
business.industry
Obstetrics and Gynecology
Retrospective cohort study
Odds ratio
Middle Aged
medicine.disease
Confidence interval
Diet
Premature ovarian failure
Reproductive Medicine
Case-Control Studies
Female
business
Developmental Biology
Subjects
Details
- ISSN :
- 14726483
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Reproductive BioMedicine Online
- Accession number :
- edsair.doi.dedup.....5df7d3ab9c99c2d45c4826b1d3681ee4