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The C(-260)T gene polymorphism in the promoter of the CD14 monocyte receptor gene is not associated with acute myocardial infarction
- Source :
- Clinical and experimental medicine. 3(3)
- Publication Year :
- 2003
-
Abstract
- CD surface molecules mediates cell activation and signaling. In particular, CD14 on blood monocytes mediate monocyte/macrophage activation by lipopolysaccharide. Lipopolysaccharide and its receptor, CD14, have been implicated in atherogenesis. It has been recently shown that a C(-260)T polymorphism in the promoter of the CD14 receptor may be a risk factor for coronary artery disease. Recently this association has been questioned because no increased risk was found with the T allele, even in the homozygous state. In the present study we investigated a possible association between the C(-260)T polymorphism in the CD14 promoter and acute myocardial infarction. Two hundred and thrteen patients with and acute myocardial infarction 213 healthy controls were included in the study. Genotype frequencies of the C(-260)T polymorphism in the CD14 promoter were determined by polimerase chain reaction and the amplified product was cleaved with HaeIII. The frequency of the T allele was not significantly different in patients compared with controls. In this study we were not able to detect differences of frequency of the allele T (-260) in the promoter of the CD 14 receptor gene in survivors of myocardial infarction and controls.
- Subjects :
- Male
Settore MED/09 - Medicina Interna
Genotype
CD14
Clinical Biochemistry
Lipopolysaccharide Receptors
Myocardial Infarction
Antigens, CD14
Polymorphism, Single Nucleotide
General Biochemistry, Genetics and Molecular Biology
Cytosine
Gene Frequency
Reference Values
Risk Factors
medicine
Humans
Reference Value
Polymorphism
Allele
Receptor
Promoter Regions, Genetic
Biochemistry, Genetics and Molecular Biology (all)
business.industry
Risk Factor
Medicine (all)
Monocyte
Smoking
Case-control study
General Medicine
Middle Aged
Molecular biology
Survival Analysis
Genotype frequency
medicine.anatomical_structure
Immunology
Settore MED/26 - Neurologia
Female
Survival Analysi
Gene polymorphism
Cell activation
business
Thymine
Human
Subjects
Details
- ISSN :
- 15918890
- Volume :
- 3
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Clinical and experimental medicine
- Accession number :
- edsair.doi.dedup.....5df6b60d35608b42bc7bf2134fbc39ee