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Altered connectivity between cerebellum, visual, and sensory-motor networks in autism spectrum disorder: Results from the EU-AIMS Longitudinal European Autism Project
- Source :
- Biological Psychiatry : Cognitive Neuroscience and Neuroimaging, 4, 3, pp. 260-270, Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, Elsevier, 2018, ⟨10.1016/j.bpsc.2018.11.010⟩, Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2018, ⟨10.1016/j.bpsc.2018.11.010⟩, Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 4(3), 260. Elsevier Inc., Oldehinkel, M, Mennes, M, Marquand, A, Charman, T, Tillmann, J, Ecker, C, Dell’acqua, F, Brandeis, D, Banaschewski, T, Baumeister, S, Moessnang, C, Holt, R, Baron-cohen, S, Bölte, S, Durston, S, Kundu, P, Lombardo, M V, Spooren, W, Loth, E, Murphy, D G M, Beckmann, C F, Buitelaar, J K, Ahmad, J, Ambrosino, S, Auyeung, B, Banaschewski, T, Baron-cohen, S, Baumeister, S, Beckmann, C F, Bölte, S, Bourgeron, T, Bours, C, Brammer, M, Brandeis, D, Brogna, C, Charman, T, Crawley, D, Ecker, C, Faulkner, J, Hayward, H, Loth, E, Lythgoe, D J, Marquand, A, Murphy, D G M, Oakley, B, Ruggeri, B, San José Cáceres, A, Simonoff, E & Tillmann, J & Williams, S C R 2019, ' Altered Connectivity Between Cerebellum, Visual, and Sensory-Motor Networks in Autism Spectrum Disorder : Results from the EU-AIMS Longitudinal European Autism Project ', Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, vol. 4, no. 3, pp. 260-270 . https://doi.org/10.1016/j.bpsc.2018.11.010, 2019, ' Altered connectivity between cerebellum, visual, and sensory-motor networks in Autism Spectrum Disorder : Results from the EU-AIMS Longitudinal European Autism Project ', Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, vol. 4, no. 3, pp. 260-270 . https://doi.org/10.1016/j.bpsc.2018.11.010, Biological Psychiatry. Cognitive Neuroscience and Neuroimaging, Biol Psychiatry Cogn Neurosci Neuroimaging, Biological Psychiatry : Cognitive Neuroscience and Neuroimaging, 4, 260-270
- Publication Year :
- 2019
-
Abstract
- BackgroundResting-state functional magnetic resonance imaging–based studies on functional connectivity in autism spectrum disorder (ASD) have generated inconsistent results. Interpretation of findings is further hampered by small samples and a focus on a limited number of networks, with networks underlying sensory processing being largely underexamined. We aimed to comprehensively characterize ASD-related alterations within and between 20 well-characterized resting-state networks using baseline data from the EU-AIMS (European Autism Interventions—A Multicentre Study for Developing New Medications) Longitudinal European Autism Project.MethodsResting-state functional magnetic resonance imaging data was available for 265 individuals with ASD (7.5–30.3 years; 73.2% male) and 218 typically developing individuals (6.9–29.8 years; 64.2% male), all with IQ > 70. We compared functional connectivity within 20 networks—obtained using independent component analysis—between the ASD and typically developing groups, and related functional connectivity within these networks to continuous (overall) autism trait severity scores derived from the Social Responsiveness Scale Second Edition across all participants. Furthermore, we investigated case-control differences and autism trait–related alterations in between-network connectivity.ResultsHigher autism traits were associated with increased connectivity within salience, medial motor, and orbitofrontal networks. However, we did not replicate previously reported case-control differences within these networks. The between-network analysis did reveal case-control differences showing on average 1) decreased connectivity of the visual association network with somatosensory, medial, and lateral motor networks, and 2) increased connectivity of the cerebellum with these sensory and motor networks in ASD compared with typically developing subjects.ConclusionsWe demonstrate ASD-related alterations in within- and between-network connectivity. The between-network alterations broadly affect connectivity between cerebellum, visual, and sensory-motor networks, potentially underlying impairments in multisensory and visual-motor integration frequently observed in ASD.
- Subjects :
- Male
Autism Spectrum Disorder
Autism
Functional connectivity
0302 clinical medicine
Cerebellum
Neural Pathways
Longitudinal Studies
10064 Neuroscience Center Zurich
Child
Visual-motor integration
Visual Cortex
Brain Mapping
medicine.diagnostic_test
05 social sciences
Sensory networks
220 Statistical Imaging Neuroscience
10058 Department of Child and Adolescent Psychiatry
Magnetic Resonance Imaging
2728 Neurology (clinical)
Autism spectrum disorder
Radiology Nuclear Medicine and imaging
10076 Center for Integrative Human Physiology
Female
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Sensorimotor Cortex
Biological psychiatry
Psychology
2803 Biological Psychiatry
Adult
2805 Cognitive Neuroscience
Autism, Cerebellum, Functional connectivity, Resting-state fMRI, Sensory networks, Visual-motor integration, Radiology, Nuclear Medicine and Imaging, Cognitive Neuroscience, Neurology (clinical), Biological Psychiatry
Adolescent
Cognitive Neuroscience
Clinical Neurology
Sensory system
610 Medicine & health
Cognitive neuroscience
050105 experimental psychology
03 medical and health sciences
Young Adult
Salience (neuroscience)
mental disorders
medicine
Humans
2741 Radiology, Nuclear Medicine and Imaging
0501 psychology and cognitive sciences
Radiology, Nuclear Medicine and imaging
Resting-state fMRI
Biological Psychiatry
Radiology
Nuclear Medicine and Imaging
Neurology (clinical)
Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7]
Resting state fMRI
medicine.disease
Case-Control Studies
Functional magnetic resonance imaging
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 24519022
- Database :
- OpenAIRE
- Journal :
- Biological Psychiatry : Cognitive Neuroscience and Neuroimaging, 4, 3, pp. 260-270, Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, Elsevier, 2018, ⟨10.1016/j.bpsc.2018.11.010⟩, Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 2018, ⟨10.1016/j.bpsc.2018.11.010⟩, Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 4(3), 260. Elsevier Inc., Oldehinkel, M, Mennes, M, Marquand, A, Charman, T, Tillmann, J, Ecker, C, Dell’acqua, F, Brandeis, D, Banaschewski, T, Baumeister, S, Moessnang, C, Holt, R, Baron-cohen, S, Bölte, S, Durston, S, Kundu, P, Lombardo, M V, Spooren, W, Loth, E, Murphy, D G M, Beckmann, C F, Buitelaar, J K, Ahmad, J, Ambrosino, S, Auyeung, B, Banaschewski, T, Baron-cohen, S, Baumeister, S, Beckmann, C F, Bölte, S, Bourgeron, T, Bours, C, Brammer, M, Brandeis, D, Brogna, C, Charman, T, Crawley, D, Ecker, C, Faulkner, J, Hayward, H, Loth, E, Lythgoe, D J, Marquand, A, Murphy, D G M, Oakley, B, Ruggeri, B, San José Cáceres, A, Simonoff, E & Tillmann, J & Williams, S C R 2019, ' Altered Connectivity Between Cerebellum, Visual, and Sensory-Motor Networks in Autism Spectrum Disorder : Results from the EU-AIMS Longitudinal European Autism Project ', Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, vol. 4, no. 3, pp. 260-270 . https://doi.org/10.1016/j.bpsc.2018.11.010, 2019, ' Altered connectivity between cerebellum, visual, and sensory-motor networks in Autism Spectrum Disorder : Results from the EU-AIMS Longitudinal European Autism Project ', Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, vol. 4, no. 3, pp. 260-270 . https://doi.org/10.1016/j.bpsc.2018.11.010, Biological Psychiatry. Cognitive Neuroscience and Neuroimaging, Biol Psychiatry Cogn Neurosci Neuroimaging, Biological Psychiatry : Cognitive Neuroscience and Neuroimaging, 4, 260-270
- Accession number :
- edsair.doi.dedup.....5df1b74e45f5812c61c6a1b2308edb6d