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Endocardial pacing site affects left ventricular end-diastolic volume and performance in the intact anesthetized dog
- Source :
- Circulation Research. 53:72-85
- Publication Year :
- 1983
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 1983.
-
Abstract
- We investigated how pacing from different endocardial sites affects the left ventricular three-dimensional contraction pattern and performance in intact anesthetized dogs. We used data from the motion of radiopaque markers implanted in the left ventricular endocardium in an analysis based on the polar decomposition theorem to determine the left ventricle's three-dimensional principal directions and magnitudes of deformation, and its axis and angle of rotation during the cardiac cycle. This paper also derives a new procedure that permits statistical comparison of different left ventricular cavity deformation patterns. During normal sinus rhythm and pacing from the right atrium, left ventricular septum, left ventricular apex, and right ventricular apex, the principal directions of left ventricular deformation remained relatively fixed with respect to the left ventricle's anatomy, independent of heart rate and pacing site. These directions were oriented in septum-free wall, anterior-posterior, and apex-base directions. End-systolic pressure and volume did not vary significantly among pacing sites. End-diastolic volume varied significantly among pacing sites, with right ventricular apical pacing producing the smallest end-diastolic and stroke volume. These results reveal that beats produced by right ventricular apical pacing eject less blood compared with beats produced by right atrial, left ventricular septal, or left ventricular apical pacing.
- Subjects :
- medicine.medical_specialty
Systole
Physiology
Heart Ventricles
Right atrial
Dogs
Diastole
Heart Rate
Internal medicine
Heart rate
Pressure
medicine
Animals
Ventricular Function
cardiovascular diseases
Cardiac Output
Normal Sinus Rhythm
Cardiac cycle
business.industry
Cardiac Pacing, Artificial
Models, Cardiovascular
Stroke volume
Anatomy
Myocardial Contraction
medicine.anatomical_structure
Ventricle
cardiovascular system
Cardiology
End-diastolic volume
Right atrium
Cardiology and Cardiovascular Medicine
business
Mathematics
Endocardium
Subjects
Details
- ISSN :
- 15244571 and 00097330
- Volume :
- 53
- Database :
- OpenAIRE
- Journal :
- Circulation Research
- Accession number :
- edsair.doi.dedup.....5dd05b40b11699b96420fa2e77b48079