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Asthma in Youth and Early-onset Type 2 Diabetes: A Nationwide Study of 1.72 Million Israeli Adolescents
- Source :
- The Journal of clinical endocrinology and metabolism. 106(12)
- Publication Year :
- 2020
-
Abstract
- Background The prevalence of both asthma and early-onset diabetes is on the rise; however, the association between them remains unclear. We examined a possible association of asthma at adolescence with type 2 diabetes in young adulthood. Methods This is a nationwide, population-based study of 1 718 541 Israeli adolescents (57% males; mean age 17.3 years; range 16-19 years), examined before compulsory military service between 1992 and 2016, with data linked to the Israeli National Diabetes Registry. Asthma diagnosis and severity were determined by a board-certified pulmonologist and based on spirometry tests. Results Type 2 diabetes developed in 58/9090 (0.64%), 507/97 059 (0.52%), 114/23 332 (0.49%), and 7095/1 589 060 (0.44%) persons with moderate-to-severe, mild, inactive, and no history of asthma, respectively, during a mean follow-up >13 years. The respective odds ratios (ORs) were 1.33 (95% CI, 1.02-1.74), 1.17 (1.06-1.28), and 1.09 (0.9-1.31), considering those without asthma history as the reference, in a model adjusted for birth year, sex, body mass index, and other sociodemographic variables. The association persisted when the analysis accounted for coexisting morbidities, and when persons without asthma, individually matched by age, sex, birth year, and body mass index were the reference. Both mild and moderate-to-severe asthma were associated with type 2 diabetes before age 35 years: ORs 1.18 (1.05-1.34) and 1.44 (1.05-2.00), respectively. The strength of the association was accentuated over time. The effect was unchanged when adjusted for oral and inhaled glucocorticoid use. Conclusion Adolescents with active asthma have higher risk to develop type 2 diabetes. This seems related to disease severity, independent of adolescent obesity status, apparent before age 35 years, and more pronounced in recent years.
- Subjects :
- Spirometry
Adult
Male
medicine.medical_specialty
Pediatrics
Pediatric Obesity
Adolescent
Endocrinology, Diabetes and Metabolism
Clinical Biochemistry
Population
Type 2 diabetes
Biochemistry
Severity of Illness Index
Body Mass Index
Young Adult
Endocrinology
Risk Factors
Diabetes mellitus
Internal medicine
medicine
Prevalence
Humans
Registries
Young adult
Israel
education
Asthma
education.field_of_study
medicine.diagnostic_test
business.industry
Biochemistry (medical)
Odds ratio
medicine.disease
Prognosis
Diabetes Mellitus, Type 2
Female
business
Body mass index
Biomarkers
Follow-Up Studies
Subjects
Details
- ISSN :
- 19457197
- Volume :
- 106
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- The Journal of clinical endocrinology and metabolism
- Accession number :
- edsair.doi.dedup.....5db948522a65127ac25c3c8305f168d6