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Fatty acid amide hydrolase inhibitors. Surprising selectivity of chiral azetidine ureas
- Source :
- Bioorganicmedicinal chemistry letters. 19(15)
- Publication Year :
- 2009
-
Abstract
- We report the discovery of a novel, chiral azetidine urea inhibitor of Fatty Acid Amide Hydrolase (FAAH,) and describe the surprising species selectivity of VER-156084 versus rat and human FAAH and also hCB1.
- Subjects :
- Stereochemistry
Chemistry, Pharmaceutical
Clinical Biochemistry
Azetidine
Pharmaceutical Science
Ether
Stereoisomerism
Biochemistry
Catalysis
Amidase
Amidohydrolases
chemistry.chemical_compound
Mice
Piperidines
Receptor, Cannabinoid, CB1
Fatty acid amide hydrolase
Drug Discovery
Animals
Humans
Urea
Enzyme Inhibitors
Molecular Biology
chemistry.chemical_classification
Mice, Knockout
biology
Organic Chemistry
Rats
Enzyme
nervous system
chemistry
Models, Chemical
Enzyme inhibitor
Drug Design
biology.protein
Molecular Medicine
Azetidines
lipids (amino acids, peptides, and proteins)
Selectivity
psychological phenomena and processes
Subjects
Details
- ISSN :
- 14643405
- Volume :
- 19
- Issue :
- 15
- Database :
- OpenAIRE
- Journal :
- Bioorganicmedicinal chemistry letters
- Accession number :
- edsair.doi.dedup.....5da69bc0152d4e578d01cb7c6a1e224e