Back to Search
Start Over
Linking paternally inherited mtDNA variants and sperm performance
- Source :
- Philos Trans R Soc Lond B Biol Sci
- Publication Year :
- 2019
-
Abstract
- Providing robust links between mitochondrial genotype and phenotype is of major importance given that mitochondrial DNA (mtDNA) variants can affect reproductive success. Because of the strict maternal inheritance (SMI) of mitochondria in animals, haplotypes that negatively affect male fertility can become fixed in populations. This phenomenon is known as ‘mother's curse’. Doubly uniparental inheritance (DUI) of mitochondria is a stable exception in bivalves, which entails two mtDNA lineages that evolve independently and are transmitted separately through oocytes and sperm. This makes the DUI mitochondrial lineages subject to different sex-specific selective sieves during mtDNA evolution, thus DUI is a unique model to evaluate how direct selection on sperm mitochondria could contribute to male reproductive fitness. In this study, we tested the impact of mtDNA variants on sperm performance and bioenergetics in DUI and SMI species. Analyses also involved measures of sperm performance following inhibition of main energy pathways and sperm response to oocyte presence. Compared to SMI, DUI sperm exhibited (i) low speed and linearity, (ii) a strict OXPHOS-dependent strategy of energy production, and (iii) a partial metabolic shift towards fermentation following egg detection. Discussion embraces the adaptive value of mtDNA variation and suggests a link between male-energetic adaptation, fertilization success and paternal mitochondria preservation.This article is part of the theme issue ‘Linking the mitochondrial genotype to phenotype: a complex endeavour’.
- Subjects :
- 0106 biological sciences
Male
Non-Mendelian inheritance
Mitochondrial DNA
Genotype
Mytilus edulis
Uniparental inheritance
Mitochondrion
Biology
010603 evolutionary biology
01 natural sciences
DNA, Mitochondrial
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
Genotype-phenotype distinction
Mercenaria
Animals
030304 developmental biology
Genetics
0303 health sciences
Haplotype
Genetic Variation
Articles
Sperm
Spermatozoa
mitochondria, OXPHOS, glycolysis, sperm, bivalves, doubly uniparental inheritance
Bivalvia
Paternal Inheritance
Maternal Inheritance
Adaptation
General Agricultural and Biological Sciences
Subjects
Details
- ISSN :
- 14712970
- Volume :
- 375
- Issue :
- 1790
- Database :
- OpenAIRE
- Journal :
- Philosophical transactions of the Royal Society of London. Series B, Biological sciences
- Accession number :
- edsair.doi.dedup.....5d92a8fd347b44d29988a3eb8c7df570