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Outcome of patients with early T1 and T2 squamous cell carcinoma of the base of tongue managed by conventional surgery with adjuvant postoperative radiation
- Source :
- Headneck. 35(7)
- Publication Year :
- 2012
-
Abstract
- Background Existing treatment regimens for squamous cell carcinoma (SCC) of the base of tongue (BOT) favor chemoradiation. However, there is a shifting paradigm toward minimally invasive surgery with adjuvant radiatiotherapy for select tumors. The aim was to report our experience in conventional surgical management with particular focus on T1/T2 tumors, which may be candidates for minimally invasive techniques. Methods Between 1985 and 2005, 128 patients were treated with primary surgery. Overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS) rates were calculated using Kaplan–Meier method, and predictive factors analyzed by univariate and multivariate analyses. Results Five-year OS, DSS, and RFS rates were 60%, 70%, and 61%, respectively. Multivariate analysis showed pathologic T classification and extracapsular extension (ECE) were significant predictors for DSS, whereas T classification remained significant for local recurrence. DSS for T1/T2 tumors ranged from 77% (node-positive) to 84% (node-negative). Conclusion T classification and ECE are independent predictors of outcome for BOT SCC. Patients with cT1/T2 tumors had excellent outcome and may be suitable for transoral robotic or endoscopic surgical procedures. © 2012 Wiley Periodicals, Inc. Head Neck, 2013
- Subjects :
- Adult
Male
medicine.medical_specialty
Multivariate analysis
medicine.medical_treatment
Disease-Free Survival
Tongue
Carcinoma
Medicine
Humans
Basal cell
Postoperative Period
Survival rate
Aged
Aged, 80 and over
business.industry
Surgical procedures
Middle Aged
medicine.disease
Prognosis
Surgery
Tongue Neoplasms
Radiation therapy
Survival Rate
medicine.anatomical_structure
Treatment Outcome
Otorhinolaryngology
Lymphatic Metastasis
Surgical Procedures, Operative
Carcinoma, Squamous Cell
Female
Radiotherapy, Adjuvant
business
Adjuvant
Follow-Up Studies
Subjects
Details
- ISSN :
- 10970347
- Volume :
- 35
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Headneck
- Accession number :
- edsair.doi.dedup.....5d894dc921e729839e740ceed8f0237a