Back to Search
Start Over
Biocatalytic approaches to a key building block for the anti-thrombotic agent ticagrelor
- Source :
- Hugentobler, K G, Sharif, H, Rasparini, M, Heath, R S & Turner, N J 2016, ' Biocatalytic approaches to a key building block for the anti-thrombotic agent ticagrelor ', Organic and Biomolecular Chemistry, vol. 14, no. 34, pp. 8064-8067 . https://doi.org/10.1039/c6ob01382a
- Publication Year :
- 2016
-
Abstract
- Three complementary biocatalytic routes were examined for the synthesis of the cyclopropyl amine (1R,2S)-2, which is a key building block for the anti-thrombotic agent ticagrelor 1. By employing either a ketoreductase, amidase or lipase biocatalyst, the key building blocks for synthesis of the amine 2 were obtained in 99.9, 92.5 and 46.3 ee, respectively.
- Subjects :
- Ticagrelor
Adenosine
Stereochemistry
Chemistry Techniques, Synthetic
010402 general chemistry
01 natural sciences
Biochemistry
Amidase
Block (programming)
medicine
Physical and Theoretical Chemistry
Lipase
Amines
biology
010405 organic chemistry
Chemistry
Hydrolysis
Organic Chemistry
Thrombosis
0104 chemical sciences
Biocatalysis
biology.protein
Key (cryptography)
Amine gas treating
medicine.drug
Subjects
Details
- ISSN :
- 14770539
- Volume :
- 14
- Issue :
- 34
- Database :
- OpenAIRE
- Journal :
- Organicbiomolecular chemistry
- Accession number :
- edsair.doi.dedup.....5d89427efe02c594feb21aa63a9ebd9a