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Fasting plasma peptide-YY concentrations are elevated but do not rise postprandially in type 2 diabetes
- Source :
- Diabetologia. 49:2219-2221
- Publication Year :
- 2006
- Publisher :
- Springer Science and Business Media LLC, 2006.
-
Abstract
- To the Editor: Weight loss appears to be particularly difficult to achieve in patients with type 2 diabetes compared to their non-diabetic counterparts [1]. The hormones peptide YY3–36 (PYY) and ghrelin are implicated in the regulation of appetite, energy balance and the pathophysiology of obesity. PYY is released from L-cells in the gut in response to food [2]. Fasting concentrations are lower and postprandial responses attenuated in obese subjects [3], and infusions of PYY to mimic the postprandial concentrations found in lean subjects reduce appetite and food intake in obese subjects [3, 4], suggesting a potential role in the pathogenesis of obesity. Peripheral administration of ghrelin increases food ingestion [5, 6], and prolonged administration leads to obesity [5, 7]. Circulating ghrelin shows preprandial peaks and postprandial troughs suggesting a role in meal initiation. Against this background, we sought to determine whether type 2 diabetes, independent of obesity status, affected the prandial regulation of PYY and ghrelin in a manner that would explain both the predisposition to increased energy intake and weight gain, and the difficulties in achieving weight loss seen in type 2 diabetes. The study was approved by the local ethics committee and subjects, who were volunteers, gave written informed consent. We studied 11 subjects with diet-controlled type 2 diabetes and 16 control subjects of similar age, sex and BMI. All subjects with diabetes were free from complications and had an HbA1c
- Subjects :
- Adult
medicine.medical_specialty
Peptide Hormones
Endocrinology, Diabetes and Metabolism
media_common.quotation_subject
Type 2 diabetes
Weight loss
Diabetes mellitus
Internal medicine
Internal Medicine
medicine
Humans
Peptide YY
media_common
business.industry
digestive, oral, and skin physiology
Appetite
Fasting
Middle Aged
Postprandial Period
medicine.disease
Ghrelin
Endocrinology
Postprandial
Diabetes Mellitus, Type 2
medicine.symptom
Thyroid function
business
Subjects
Details
- ISSN :
- 14320428 and 0012186X
- Volume :
- 49
- Database :
- OpenAIRE
- Journal :
- Diabetologia
- Accession number :
- edsair.doi.dedup.....5d874b0ba9a8419364dc5143bd19e506