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Decreased production of proinflammatory cytokines by monocytes from individuals presenting Candida-associated denture stomatitis
- Source :
- Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP
- Publication Year :
- 2016
-
Abstract
- Candida-associated denture stomatitis (DS) is the most frequent lesion among denture wearers, especially the elderly. DS is strongly associated with Candida albicans, as well as local and systemic factors, such as impaired immune response. Monocytes are important in the protective immune response against the fungus by the production of cytokines that recruit and activate leukocytes. There are functional changes in these cells with age, and individual alterations involving monocyte response may predispose the host to developing infections by Candida spp. In this study, our aim was to evaluate the production of TNF-α, IL-6, CXCL8, IL-1β, MCP-1 and IL-10 by monocytes from elderly denture wearers with/without DS and elderly or young non-denture wearers. We detected that monocytes from elderly denture wearers with Candida-related denture stomatitis produced lower levels of CXCL-8, IL-6 and MCP-1. This imbalance in cytokine levels was observed in spontaneous or LPS-stimulated production. Therefore, our data suggested that inherent aspects of the host, such as changes in cytokine production by monocytes, might be associated with the development and the persistence of DS irrespective of aging.
- Subjects :
- Adult
Male
0301 basic medicine
medicine.medical_treatment
Immunology
Enzyme-Linked Immunosorbent Assay
Biochemistry
Monocytes
Proinflammatory cytokine
03 medical and health sciences
0302 clinical medicine
Immune system
Species Specificity
Candida albicans
medicine
Humans
Immunology and Allergy
Candida tropicalis
Interleukin 8
Interleukin 6
Molecular Biology
Stomatitis
Chemokine CCL2
Aged
Candida
Aged, 80 and over
IDOSOS
biology
Interleukin-6
Monocyte
Interleukin-8
Candidiasis
030206 dentistry
Hematology
Middle Aged
biology.organism_classification
medicine.disease
Stomatitis, Denture
030104 developmental biology
medicine.anatomical_structure
Cytokine
Host-Pathogen Interactions
biology.protein
Cytokines
Female
Inflammation Mediators
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP
- Accession number :
- edsair.doi.dedup.....5d77af4ec34b72cc7a58fe0297f5e23e