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Hepatoprotective and Anti-Hepatitis C Viral Activity of Platycodon grandiflorum Extract on Carbon Tetrachloride-Induced Acute Hepatic Injury in Mice
- Source :
- Journal of Nutritional Science and Vitaminology. 58:187-194
- Publication Year :
- 2012
- Publisher :
- Center for Academic Publications Japan, 2012.
-
Abstract
- The present study aims to evaluate the anti-HCV activity of hotwater extract from Platycodon grandiflorum (BC703) with HCV genotype 1b subgenomic replicon system and investigate its hepatoprotective activity on carbon tetrachloride (CCl(4))-induced acute liver damage in mice. BC703 produced significant hepatoprotective effects against CCl(4)-induced acute hepatic injury by decreasing the activities of serum enzymes, nitric oxide and lipid peroxidation. Histopathological studies further substantiated the protective effect of BC703. Furthermore, BC703 inhibited the HCV RNA replication with an EC(50) value and selective index (CC(50)/EC(50)) of 2.82 µg/mL and above 35.46, respectively. However, digested BC703 using a simulated gastric juice showed poor protective effect against CCl(4)-induced hepatotoxicity in mice and decreased anti-HCV activity as compared to the intact BC703. Although further studies are necessary, BC703 may be a beneficial agent for the management of acute hepatic injury and chronic HCV infection.
- Subjects :
- Male
Platycodon
Hepatitis C virus
Medicine (miscellaneous)
Hepacivirus
Pharmacology
medicine.disease_cause
Subgenomic replicon
Nitric oxide
Lipid peroxidation
Mice
chemistry.chemical_compound
Genotype 1b
medicine
Animals
Liver damage
Mice, Inbred ICR
Hepatitis c viral
Nutrition and Dietetics
Plant Extracts
Hepatitis C
digestive system diseases
chemistry
Carbon tetrachloride
Chemical and Drug Induced Liver Injury
Phytotherapy
Subjects
Details
- ISSN :
- 18817742 and 03014800
- Volume :
- 58
- Database :
- OpenAIRE
- Journal :
- Journal of Nutritional Science and Vitaminology
- Accession number :
- edsair.doi.dedup.....5d76cb77aad03bf1a0c7184cd8787ca4