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Outcome of deceased donor renal transplantation - a single-center experience from developing country
- Source :
- Saudi Journal of Kidney Diseases and Transplantation, Vol 24, Iss 2, Pp 403-407 (2013)
- Publication Year :
- 2013
-
Abstract
- Renal transplantation (RTx) is considered as the best therapeutic modality for patient suffering from end-stage renal disease (ESRD). Dearth of donor kidneys is a major problem everywhere, and deceased donor renal transplantation (DDRTx) is seen as at least a partial solution. Even so, DDRTx accounts for only less than 4% of RTx in India. We report our 6-year single-center experience on DDRTx vis-a-vis patient/graft survival, graft function in terms of serum creatinine (SCr), rejection episodes, and delayed graft function (DGF). Between January 2005 and March 2011, 236 DDRTx were performed. Majority of the donors were those with brain death due to road traffic/cerebrovascular accidents. The commonest recipient diseases leading to ESRD were chronic glomerulonephritis (42.8%), diabetes (12.7%), and hypertension (10.6%). Mean recipient age was 36.2 ± 14.2 years; 162 were males and 74 were females. Mean donor age was 45.3 ± 17.13 years; 144 were males and 92 were females. Mean dialysis duration pre-transplantation was 18.5 ± 2.5 months. All recipients received single-dose rabbit-anti-thymocyte globulin induction and steroids, calcinueurin inhibitor, and mycophenolate mofetil/azathioprine for maintenance immunosuppression. Delayed graft function was observed in 29.6% patients and 22% had biopsy-proven acute rejection. Over the mean follow-up of 2.18 ± 1.75 years, patient and graft survival rates were 74.57% and 86.8%, respectively, with mean SCr of 1.42 ± 0.66 mg%. DDRTx achieves acceptable graft function with patient/graft survival, encouraging the use of this approach in view of organ shortage.
- Subjects :
- Adult
Graft Rejection
Male
medicine.medical_specialty
Brain Death
Time Factors
medicine.medical_treatment
lcsh:Medicine
Delayed Graft Function
India
Azathioprine
Disease
Single Center
Donor Selection
chemistry.chemical_compound
Diabetes mellitus
medicine
Humans
Developing Countries
Dialysis
Retrospective Studies
Creatinine
business.industry
lcsh:R
Graft Survival
Immunosuppression
General Medicine
Middle Aged
medicine.disease
Kidney Transplantation
Survival Analysis
Tissue Donors
Surgery
Transplantation
Treatment Outcome
chemistry
Kidney Failure, Chronic
Female
business
Immunosuppressive Agents
medicine.drug
Subjects
Details
- ISSN :
- 13192442
- Volume :
- 24
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia
- Accession number :
- edsair.doi.dedup.....5d74f276e53ae101dcda6501f6a66fee