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Magnetic resonance spectroscopy of isoflurane kinetics in humans. Part II: Functional localization
- Source :
- British Journal of Anaesthesia. 79:586-589
- Publication Year :
- 1997
- Publisher :
- Elsevier BV, 1997.
-
Abstract
- We describe the first experiments to relate the cerebral kinetics of isoflurane (determined by fluorine magnetic resonance spectroscopy) to cerebral function. Using a surface receive coil we found two-compartment kinetics within the head with equilibrium half-times of 3.5 min and approximately 1 h with respect to expired isoflurane concentrations. Using critical fusion flicker frequency as an objective measure of the cerebral effect of isoflurane, we found evidence to identify the fast component as the brain. Responsiveness to command was lost at a brain partial pressure of 0.3% isoflurane. We conclude that the measured cerebral kinetics of isoflurane exactly matched the predictions of the classical perfusion-limited model.
- Subjects :
- Magnetic Resonance Spectroscopy
Isoflurane
business.industry
Partial Pressure
Kinetics
Brain
Partial pressure
Nuclear magnetic resonance spectroscopy
Models, Biological
Flicker Fusion
Anesthesiology and Pain Medicine
Nuclear magnetic resonance
Anesthesia
Anesthetics, Inhalation
Cerebral function
Humans
Medicine
Computer Simulation
business
Perfusion
medicine.drug
Subjects
Details
- ISSN :
- 00070912
- Volume :
- 79
- Database :
- OpenAIRE
- Journal :
- British Journal of Anaesthesia
- Accession number :
- edsair.doi.dedup.....5d713a766b1c423bcd084932873f0ff6