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Neutrophil CD11b Expression and Circulating Interleukin-8 as Diagnostic Markers for Early-Onset Neonatal Sepsis
- Source :
- Pediatrics. 108:e12-e12
- Publication Year :
- 2001
- Publisher :
- American Academy of Pediatrics (AAP), 2001.
-
Abstract
- Objective.To assess neutrophil CD11b and circulating interleukin 8 (IL-8) as markers of early-onset infection in neonates.Methods.The study comprised 39 neonates, with a gestational age of 29 to 41 weeks, suspected of infection within 48 hours of life. Neutrophil surface expression of CD11b was quantified with flow cytometry and plasma IL-8 with an enzyme-linked immunosorbent assay. Both data were available from 35 of 39 neonates. Serum C-reactive protein was determined at initial evaluation and, later, on the basis of the clinical picture. Neonates were allocated retrospectively into 2 groups. In the sepsis group (N = 22), 4 had culture-proven sepsis, and 14 had an antenatal risk factor for infection. In the possible-infection group (N = 13), each neonate had a noninfective disorder, but co-occurring infection remained a possibility. Twelve healthy term infants served as controls.Results.CD11b expression and IL-8 levels both increased in order of sepsis > possible infection > healthy. Sensitivity and specificity by the CD11b test for sepsis were equal, at 1.00, and those by the IL-8 test 0.91 and 1.00, respectively; 6 (17.1%) of the 35 neonates had CD11b and IL-8 below cutoff levels.Conclusions.Measuring neutrophil CD11b expression and circulating IL-8 provides a means to identify early-onset neonatal sepsis. The findings may be helpful in planning strategies to safely reduce the use of antimicrobials in neonates.
- Subjects :
- Time Factors
Neutrophils
Sensitivity and Specificity
Sepsis
03 medical and health sciences
0302 clinical medicine
Predictive Value of Tests
030225 pediatrics
medicine
Humans
Prospective Studies
Interleukin 8
Risk factor
Prospective cohort study
030304 developmental biology
0303 health sciences
Neonatal sepsis
biology
CD11 Antigens
business.industry
Interleukin-8
C-reactive protein
Infant, Newborn
Gestational age
medicine.disease
3. Good health
Predictive value of tests
Pediatrics, Perinatology and Child Health
Immunology
biology.protein
business
Biomarkers
Subjects
Details
- ISSN :
- 10984275 and 00314005
- Volume :
- 108
- Database :
- OpenAIRE
- Journal :
- Pediatrics
- Accession number :
- edsair.doi.dedup.....5d6fb60758399ffff8c9e792888d13b7