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Local circuit amplification of spatial selectivity in the hippocampus
- Source :
- Nature
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Local circuit architecture facilitates the emergence of feature selectivity in the cerebral cortex1. In the hippocampus, it remains unknown whether local computations supported by specific connectivity motifs2 regulate the spatial receptive fields of pyramidal cells3. Here we developed an in vivo electroporation method for monosynaptic retrograde tracing4 and optogenetics manipulation at single-cell resolution to interrogate the dynamic interaction of place cells with their microcircuitry during navigation. We found a local circuit mechanism in CA1 whereby the spatial tuning of an individual place cell can propagate to a functionally recurrent subnetwork5 to which it belongs. The emergence of place fields in individual neurons led to the development of inverse selectivity in a subset of their presynaptic interneurons, and recruited functionally coupled place cells at that location. Thus, the spatial selectivity of single CA1 neurons is amplified through local circuit plasticity to enable effective multi-neuronal representations that can flexibly scale environmental features locally without degrading the feedforward input structure. Single-cell tracing and optogenetics manipulation in mice are used to show how spatial tuning of individual pyramidal cells in CA1 can propagate to and be amplified by their local subnetwork of neurons.
- Subjects :
- Male
General Science & Technology
Computer science
Presynaptic Terminals
Place cell
Hippocampus
Optogenetics
Article
Mice
SYNAPTIC PLASTICITY
Interneurons
Neural Pathways
Biological neural network
Animals
Cell Lineage
NETWORK
CA1 Region, Hippocampal
Spatial Memory
Network model
Science & Technology
Multidisciplinary
Pyramidal Cells
Electroporation
Feed forward
Neural Inhibition
Multidisciplinary Sciences
CA1 PLACE
Place Cells
nervous system
Receptive field
Science & Technology - Other Topics
Female
Single-Cell Analysis
Neuroscience
FUNCTIONAL-ORGANIZATION
Spatial Navigation
Subjects
Details
- ISSN :
- 14764687 and 00280836
- Volume :
- 601
- Database :
- OpenAIRE
- Journal :
- Nature
- Accession number :
- edsair.doi.dedup.....5d687d5f2f1cf9d5bfbae8dbc3c3fe0d