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Association of the Gly482Ser PPARGC1A gene variant with different cholesterol outcomes in response to two energy-restricted diets in subjects with excessive weight
- Source :
- Nutrition (Burbank, Los Angeles County, Calif.). 47
- Publication Year :
- 2017
-
Abstract
- Objectives The aim of this study was to investigate the influence of two PPARGC1A gene polymorphisms on metabolic outcomes in response to two energy-restricted diets. Methods A 4-mo nutritional intervention was conducted that involved two different hypo-energetic diets based on low-fat (LF) and moderately high-protein (MHP) dietary patterns. Unrelated subjects with excessive weight were genotyped for two PPARGC1A polymorphisms: Rs8192678 (Gly482Ser) and rs3755863 (G > A). Genotyping was performed by next-generation sequencing and haplotypes were screened. Anthropometric measurements and biochemical tests were assessed with standardized methods. Results Different cholesterol outcomes were observed by diet and Gly482Ser genotype. The Gly482 Gly homozygotes after an LF diet had lower reductions in total cholesterol (−9 mg/dL vs. −27 mg/dL; P = 0.017) and low-density lipoprotein cholesterol levels (−5 mg/dL vs. −18 mg/dL; P = 0.016) than the subjects who were carriers of 482 Ser allele. However, this finding was not recorded in the MHP group where Gly482 Gly homozygotes underwent similar cholesterol decreases as the 482 Ser allele carriers. Likewise, all genotype carriers had significant reductions in the frequencies of hypercholesterolemia (total cholesterol ≥200 mg/dL) except for Gly482 Gly homozygotes in the LF group. Meanwhile, the rs3755863 polymorphism and PPARGC1A haplotypes showed borderline effects with regard to cholesterol decreases. Conclusions An energy-restricted MHP diet might be more beneficial than an LF diet to reduce serum cholesterol among subjects who are carriers of the PPARGC1A Gly482Gly genotype. The analysis of this genetic variant might be the basis for a precise, nutrigenetic management of hypercholesterolemia based on genetic makeup.
- Subjects :
- 0301 basic medicine
Adult
Male
medicine.medical_specialty
Genotype
Endocrinology, Diabetes and Metabolism
Hypercholesterolemia
030209 endocrinology & metabolism
Nutrigenetics
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Nutrigenomics
Polymorphism (computer science)
Internal medicine
medicine
Humans
Obesity
Prospective Studies
Allele
Diet, Fat-Restricted
Alleles
030109 nutrition & dietetics
Nutrition and Dietetics
Polymorphism, Genetic
Anthropometry
business.industry
Cholesterol
Haplotype
Middle Aged
medicine.disease
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
Lipoproteins, LDL
Endocrinology
Treatment Outcome
chemistry
Haplotypes
Diet, High-Protein
Female
PPARGC1A
business
Subjects
Details
- ISSN :
- 18731244
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Nutrition (Burbank, Los Angeles County, Calif.)
- Accession number :
- edsair.doi.dedup.....5d4b99e56cf633507df5a6612b2732ea