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Pharmacologic Approach to Sinoatrial Node Dysfunction

Authors :
Isabelle Bidaud
Matteo E. Mangoni
Angelo G. Torrente
Vadim V. Fedorov
Peter J. Mohler
P. Mesirca
Thomas J. Hund
Institut de Génomique Fonctionnelle (IGF)
Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS)
Ion Channel Science and Therapeutics
Laboratories of Excellence
Ohio State University [Columbus] (OSU)
Internal Medicine and of Physiology & Cell Biology, The Ohio State University
Department of Biomedical Engineering [Colombus]
Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)
Guerineau, Nathalie C.
Source :
Annual Review of Pharmacology and Toxicology, Annual Review of Pharmacology and Toxicology, Annual Reviews, 2021, 61, pp.757-778. ⟨10.1146/annurev-pharmtox-031120-115815⟩, Annu Rev Pharmacol Toxicol, Annual Review of Pharmacology and Toxicology, 2021, 61, pp.757-778. ⟨10.1146/annurev-pharmtox-031120-115815⟩
Publication Year :
2021
Publisher :
HAL CCSD, 2021.

Abstract

The spontaneous activity of the sinoatrial node initiates the heartbeat. Sino-atrial node dysfunction (SND) and sick sinoatrial (sick sinus) syndrome are caused by the heart's inability to generate a normal sinoatrial node action potential. In clinical practice, SND is generally considered an age-related pathology, secondary to degenerative fibrosis of the heart pacemaker tissue. However, other forms of SND exist, including idiopathic primary SND, which is genetic, and forms that are secondary to cardiovascular or systemic disease. The incidence of SND in the general population is expected to increase over the next half century, boosting the need to implant electronic pacemakers. During the last two decades, our knowledge of sino-atrial node physiology and of the pathophysiological mechanisms underlying SND has advanced considerably. This review summarizes the current knowledge about SND mechanisms and discusses the possibility of introducing new pharmacologic therapies for treating SND.

Details

Language :
English
ISSN :
03621642
Database :
OpenAIRE
Journal :
Annual Review of Pharmacology and Toxicology, Annual Review of Pharmacology and Toxicology, Annual Reviews, 2021, 61, pp.757-778. ⟨10.1146/annurev-pharmtox-031120-115815⟩, Annu Rev Pharmacol Toxicol, Annual Review of Pharmacology and Toxicology, 2021, 61, pp.757-778. ⟨10.1146/annurev-pharmtox-031120-115815⟩
Accession number :
edsair.doi.dedup.....5d4a460ff1568ea5aec51338432c2ba0
Full Text :
https://doi.org/10.1146/annurev-pharmtox-031120-115815⟩