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Pharmacologic Approach to Sinoatrial Node Dysfunction
- Source :
- Annual Review of Pharmacology and Toxicology, Annual Review of Pharmacology and Toxicology, Annual Reviews, 2021, 61, pp.757-778. ⟨10.1146/annurev-pharmtox-031120-115815⟩, Annu Rev Pharmacol Toxicol, Annual Review of Pharmacology and Toxicology, 2021, 61, pp.757-778. ⟨10.1146/annurev-pharmtox-031120-115815⟩
- Publication Year :
- 2021
- Publisher :
- HAL CCSD, 2021.
-
Abstract
- The spontaneous activity of the sinoatrial node initiates the heartbeat. Sino-atrial node dysfunction (SND) and sick sinoatrial (sick sinus) syndrome are caused by the heart's inability to generate a normal sinoatrial node action potential. In clinical practice, SND is generally considered an age-related pathology, secondary to degenerative fibrosis of the heart pacemaker tissue. However, other forms of SND exist, including idiopathic primary SND, which is genetic, and forms that are secondary to cardiovascular or systemic disease. The incidence of SND in the general population is expected to increase over the next half century, boosting the need to implant electronic pacemakers. During the last two decades, our knowledge of sino-atrial node physiology and of the pathophysiological mechanisms underlying SND has advanced considerably. This review summarizes the current knowledge about SND mechanisms and discusses the possibility of introducing new pharmacologic therapies for treating SND.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
[SDV]Life Sciences [q-bio]
Population
030204 cardiovascular system & hematology
Toxicology
Article
Sinoatrial node dysfunction
03 medical and health sciences
Heart pacemaker tissue
0302 clinical medicine
Heart Conduction System
Internal medicine
medicine
Humans
education
Sinoatrial Node
Pharmacology
Sick Sinus Syndrome
education.field_of_study
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology
Sinoatrial node
business.industry
Sick sinus
Tertiapin-Q
3. Good health
[SDV] Life Sciences [q-bio]
Clinical Practice
030104 developmental biology
medicine.anatomical_structure
Cardiology
business
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Subjects
Details
- Language :
- English
- ISSN :
- 03621642
- Database :
- OpenAIRE
- Journal :
- Annual Review of Pharmacology and Toxicology, Annual Review of Pharmacology and Toxicology, Annual Reviews, 2021, 61, pp.757-778. ⟨10.1146/annurev-pharmtox-031120-115815⟩, Annu Rev Pharmacol Toxicol, Annual Review of Pharmacology and Toxicology, 2021, 61, pp.757-778. ⟨10.1146/annurev-pharmtox-031120-115815⟩
- Accession number :
- edsair.doi.dedup.....5d4a460ff1568ea5aec51338432c2ba0
- Full Text :
- https://doi.org/10.1146/annurev-pharmtox-031120-115815⟩