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The efficacy of monopyridinium (2-PAAM, 2-PAEM) and bispyridinium (obidoxime, HI-6) oximes against mevinphos in mice
- Source :
- Pharmacologytoxicology. 81(3)
- Publication Year :
- 1997
-
Abstract
- The efficacy of two new monopyridinium oximes (2-PAAM, 2-PAEM) and two bispyridinium oximes (obidoxime. HI-6) was tested in combination with atropine sulphate against acute poisoning with the organophosphorus insecticide mevinphos in mice. When mice were treated two min. after mevinphos poisoning, no significant differences in the therapeutic effect of tested oximes were observed. The oximes increased the 24 hr LD50 values of mevinphos about two times in comparison with the 24 hr LD50 values of mevinphos in mice protected with atropine sulphate alone and more than three times in comparison with non-treated intoxicated animals. On the other hand, both monopyridinium oximes were significantly more efficacious than HI-6 and as efficacious as obidoxime when they were administered 30 sec. after mevinphos poisoning. Both monopyridinium oximes and obidoxime increased the 24 hr values of mevinphos almost three times in comparison with the 24 hr values of mevinphos in mice protected with atropine sulphate alone and about twenty-five times in comparison with non-treated intoxicated animals, while the oxime HI-6 less than two times in comparison with the 24 hr values of mevinphos in mice protected with atropine sulphate alone and about fifteen times in comparison with non-treated intoxicated animals. Use of new monopyridinium oximes seems to be the improvement in the antidotal treatment of poisoning with organophosphorous insecticide mevinphos in comparison with HI-6 but not in comparison with obidoxime when oximes are used in equimolar doses.
- Subjects :
- Obidoxime
Atropine
Male
Cholinesterase Reactivators
Insecticides
Obidoxime Chloride
Health, Toxicology and Mutagenesis
medicine.medical_treatment
Pyridinium Compounds
Muscarinic Antagonists
Pharmacology
Toxicology
Median lethal dose
Parasympatholytic
Lethal Dose 50
chemistry.chemical_compound
Mice
Structure-Activity Relationship
Oximes
medicine
Animals
Antidote
Oxime
Acute toxicity
chemistry
Mevinphos
medicine.drug
Subjects
Details
- ISSN :
- 09019928
- Volume :
- 81
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Pharmacologytoxicology
- Accession number :
- edsair.doi.dedup.....5d49acc2c8f62bf22132c048b7b270d9