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Supplementation of quinoa regulates glycolipid metabolism and endoplasmic reticulum stress in the high-fat diet-induced female obese mice
- Source :
- Nutrition & Metabolism, Nutrition & Metabolism, Vol 18, Iss 1, Pp 1-11 (2021)
- Publication Year :
- 2021
- Publisher :
- BioMed Central, 2021.
-
Abstract
- Objective To explore the effects of the quinoa diet on glycolipid metabolism and endoplasmic reticulum (ER) stress in an obese mouse model. Methods Six-week-old C57BL/6J female mice have received a high-fat diet (HFD) to induce obesity and subsequently were treated with a quinoa diet for 12 weeks. During this period, fasting blood glucose, body fat and insulin resistance were measured regularly. At the end of the experiment, mouse serum and liver tissue were collected. The differences in glucose and lipid metabolism were analyzed, and liver tissue pathological morphology, liver endoplasmic reticulum stress-related mRNA and protein levels, and serum oxidative stress levels were measured. Results Quinoa diet could significantly reduce the level of blood glucose, triglyceride, cholesterol, low-density lipoprotein, improve glucose tolerance, as well as improve histological changes of liver tissues in obese mice (P P P Conclusions Quinoa supplementation can improve glycolipid metabolism, regulate ER stress, and alleviate obesity in HFD-induced mice.
- Subjects :
- medicine.medical_specialty
RC620-627
Endocrinology, Diabetes and Metabolism
Medicine (miscellaneous)
medicine.disease_cause
chemistry.chemical_compound
Insulin resistance
Internal medicine
medicine
TX341-641
Nutritional diseases. Deficiency diseases
Nutrition and Dietetics
Triglyceride
Nutrition. Foods and food supply
Cholesterol
business.industry
High-fat diet-induced obesity
Endoplasmic reticulum
Research
Lipid metabolism
medicine.disease
Endocrinology
chemistry
Oxidative stress
Quinoa
Unfolded protein response
Endoplasmic reticulum stress
business
Glycolipid metabolism
Lipoprotein
Subjects
Details
- Language :
- English
- ISSN :
- 17437075
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Nutrition & Metabolism
- Accession number :
- edsair.doi.dedup.....5d35e095e954336ccdf2cdef6882ee64