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Simple and convenient access to α,α,α-trisubstituted amides by double addition of Grignard reagents to acyl cyanohydrins
- Source :
- Chemical Communications, Chemical Communications, Royal Society of Chemistry, 2012, 48 (69), pp.8655-8657. ⟨10.1039/c2cc34841a⟩, Chemical Communications, Royal Society of Chemistry, 2012, 48 (69), pp.8655. ⟨10.1039/c2cc34841a⟩
- Publication Year :
- 2012
-
Abstract
- The double addition of Grignard (alkyl, aryl, alkenyl, alkynyl) reagents to acyl cyanohydrins was performed under unusually smooth conditions with a concomitant O–N acyl transfer, providing a very simple and general access to α,α,α-trisubstituted amides.
- Subjects :
- chemistry.chemical_classification
010405 organic chemistry
Chemistry
[CHIM.ORGA]Chemical Sciences/Organic chemistry
Aryl
Metals and Alloys
Nucleophilic acyl substitution
General Chemistry
010402 general chemistry
01 natural sciences
Medicinal chemistry
Catalysis
3. Good health
0104 chemical sciences
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
chemistry.chemical_compound
Reagent
Materials Chemistry
Ceramics and Composites
Organic chemistry
[CHIM]Chemical Sciences
lipids (amino acids, peptides, and proteins)
Alkyl
ComputingMilieux_MISCELLANEOUS
Subjects
Details
- ISSN :
- 1364548X and 13597345
- Volume :
- 48
- Issue :
- 69
- Database :
- OpenAIRE
- Journal :
- Chemical communications (Cambridge, England)
- Accession number :
- edsair.doi.dedup.....5d2c1303e166a603731a507345850a16