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Human papillomavirus infection in women in Puerto Rico: agreement between physician-collected and self-collected anogenital specimens
- Source :
- Journal of lower genital tract disease, vol 17, iss 2
- Publication Year :
- 2013
- Publisher :
- eScholarship, University of California, 2013.
-
Abstract
- ObjectiveThis study aimed to describe the prevalence and concordance between cervical and anal human papillomavirus (HPV) infection and compare cervicovaginal and anal self-collection methods for HPV testing between physician and self-collected specimens in women in Puerto Rico.Materials and methodsSpecimens for HPV-DNA testing were obtained from 100 women aged 18 to 34 years attending a general gynecology clinic for a routine Pap smear. Human papillomavirus testing was performed using polymerase chain reaction MY09/MY11 primers. Positive samples were typed for 39 genotypes. Agreement between sampling methods was determined by percent agreement and the κ statistic.ResultsFor the 39 genotypes evaluated, 38.4% (38/99) of cervicovaginal and 33.7% (30/89) of anal physician-collected samples were HPV+, whereas 35.1% (34/97) of cervicovaginal and 32.0% (31/97) of anal self-collected samples were positive. Human papillomavirus type 16 was the most common type identified in the cervix (8.3%, 8/97) and the anus (5.6%, 5/89) of physician-collected samples, with similar prevalence in self-collected samples. Concordance between cervical and anal HPV infection was high (>90%) for all types evaluated. There was a strong percent agreement between physician- and self-collected cervicovaginal and anal samples (>95% for all HPV types) and good to excellent agreement (κ > 0.60) for most HPV types.ConclusionsThe clinic-based prevalence of anal and cervicovaginal HPV infection was high, with a strong concordance between cervical and anal infection and good to excellent agreement between physician- and self-collected samples. This study supports the feasibility of using cervical and anal self-sampling methods in future population-based studies of HPV infection in Puerto Rico and as an HPV screening method in women.
- Subjects :
- cervical cancer
Self Administration
Uterine Cervical Diseases
Ambulatory Care
Prevalence
Medicine
Viral
Young adult
Dna viral
Papillomaviridae
human papillomavirus
Cancer
biology
virus diseases
Obstetrics and Gynecology
self-sampling
General Medicine
Hpv testing
Infectious Diseases
Female
Infection
geographic locations
Adult
medicine.medical_specialty
Genotype
Adolescent
anal cancer
Concordance
Clinical Sciences
Article
Specimen Handling
Young Adult
Viral genetics
Clinical Research
Humans
Human papillomavirus
Obstetrics & Reproductive Medicine
Gynecology
Anus Diseases
business.industry
screening
Papillomavirus Infections
Puerto Rico
DNA
biology.organism_classification
DNA, Viral
Sexually Transmitted Infections
business
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Journal of lower genital tract disease, vol 17, iss 2
- Accession number :
- edsair.doi.dedup.....5d2179b92a241ec2fc4416a6cbf969e9