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COVID-19 in an international European liver transplant recipient cohort
- Source :
- Gut, Gut, vol. 69, no. 10, pp. 1832-1840, Gut, 69(10), 1832-1840. BMJ PUBLISHING GROUP, Gut, Vol. 69, no. 10, p. 1832-1840 (2020)
- Publication Year :
- 2020
- Publisher :
- BMJ PUBLISHING GROUP, 2020.
-
Abstract
- ObjectiveKnowledge on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in liver transplant recipients is lacking, particularly in terms of severity of the disease. The aim of this study was to describe the demographic, baseline clinical characteristics and early outcomes of a European cohort of liver transplant recipients with SARS-CoV-2 infection.DesignWe conducted an international prospective study across Europe on liver transplant recipients with SARS-CoV-2 infection confirmed by microbiological assay during the first outbreak of COVID-19 pandemic. Baseline characteristics, clinical presentation, management of immunosuppressive therapy and outcomes were collected.Results57 patients were included (70% male, median (IQR) age at diagnosis 65 (57–70) years). 21 (37%), 32 (56%) and 21 (37%) patients had one cardiovascular disease, arterial hypertension and diabetes mellitus, respectively. The most common symptoms were fever (79%), cough (55%), dyspnoea (46%), fatigue or myalgia (56%) and GI symptoms (33%). Immunosuppression was reduced in 22 recipients (37%) and discontinued in 4 (7%). With this regard, no impact on outcome was observed. Forty-one (72%) subjects were hospitalised and 11 (19%) developed acute respiratory distress syndrome. Overall, we estimated a case fatality rate of 12% (95% CI 5% to 24%), which increased to 17% (95% CI 7% to 32%) among hospitalised patients. Five out of the seven patients who died had a history of cancer.ConclusionIn this European multicentre prospective study of liver transplant recipients, COVID-19 was associated with an overall and in-hospital fatality rate of 12% (95% CI 5% to 24%) and 17% (95% CI 7% to 32%), respectively. A history of cancer was more frequent in patients with poorer outcome.
- Subjects :
- myalgia
Male
medicine.medical_specialty
medicine.medical_treatment
infectious disease
Pneumonia, Viral
030230 surgery
Liver transplantation
Chronic liver disease
Cohort Studies
03 medical and health sciences
Betacoronavirus
chronic liver disease
orthotopic liver transplantation
0302 clinical medicine
Internal medicine
Case fatality rate
medicine
Humans
Prospective Studies
Prospective cohort study
610 Medicine & health
Survival rate
Pandemics
Aged
Hepatology
business.industry
SARS-CoV-2
Liver Diseases
Gastroenterology
COVID-19
Middle Aged
medicine.disease
Liver Transplantation
Europe
Hospitalization
Survival Rate
Coronavirus Infections/diagnosis
Coronavirus Infections/epidemiology
Coronavirus Infections/therapy
Female
Liver Diseases/mortality
Liver Diseases/surgery
Liver Diseases/virology
Pneumonia, Viral/diagnosis
Pneumonia, Viral/epidemiology
Pneumonia, Viral/therapy
Cohort
030211 gastroenterology & hepatology
medicine.symptom
business
Coronavirus Infections
Cohort study
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Gut, Gut, vol. 69, no. 10, pp. 1832-1840, Gut, 69(10), 1832-1840. BMJ PUBLISHING GROUP, Gut, Vol. 69, no. 10, p. 1832-1840 (2020)
- Accession number :
- edsair.doi.dedup.....5d18fff6d03a2635a6545c061f6383e9