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Ethnopharmacology and bioinformatic combination for leads discovery: application to phospholipase A(2) inhibitors
- Source :
- Phytochemistry. 58(6)
- Publication Year :
- 2001
-
Abstract
- A program combining ethnopharmacology and bioinformatic approaches has successfully been applied on anti-inflammatory activity. (i) An ethnobotanical study allowed the identification of several plants associated with putative anti-inflammatory properties as potential leads. (ii) On the other hand, it is well known that phospholipase A(2) is a target implicated in the pro-inflammatory process. Thus, (iii) some selected plant extracts were experimentally tested on phospholipase A(2). Finally, (iv) these experimental results combined with bioinformatic tools, such as database exploitation and molecular modeling, allowed to suggest that one compound, betulin and its oxidative form betulinic acid, might be responsible of the anti-PLA(2) activity. This suggestion was confirmed experimentally.
- Subjects :
- Models, Molecular
Molecular model
Phospholipase A2 inhibitor
Plant Science
Horticulture
Biology
Biochemistry
Phospholipases A
chemistry.chemical_compound
Phospholipase A2
Species Specificity
Betulinic acid
Enzyme Inhibitors
Molecular Biology
Chromatography, High Pressure Liquid
chemistry.chemical_classification
Phospholipase A
Betulin
Molecular Structure
Plant Extracts
Computational Biology
General Medicine
Enzyme
chemistry
Enzyme inhibitor
Drug Design
Ethnopharmacology
biology.protein
Subjects
Details
- ISSN :
- 00319422
- Volume :
- 58
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Phytochemistry
- Accession number :
- edsair.doi.dedup.....5d0a5b600da47751319a3ab92f2b77be