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Super-quenched Molecular Probe Based on Aggregation-Induced Emission and Photoinduced Electron Transfer Mechanisms for Formaldehyde Detection in Human Serum
- Source :
- Chemistry - An Asian Journal. 13:1432-1437
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- Energy transfer between fluorescent dyes and quenchers is widely used in the design of light-up probes. Although dual quenchers are more effective in offering lower background signals and higher turn-on ratios than one quencher, such probes are less explored in practice as they require both quenchers to be within the proximity of the fluorescent core. In this contribution, we utilized intramolecular motion and photoinduced electron transfer (PET) as quenching mechanisms to build super-quenched light-up probes based on fluorogens with aggregation-induced emission. The optimized light-up probe possesses negligible background and is able to detect not only free formaldehyde (FA) but also polymeric FA, with an unprecedented turn-on ratio of >4900. We envision that this novel dual quenching strategy will help to develop various light-up probes for analyte sensing.
- Subjects :
- Analyte
Polymers
Formaldehyde
010402 general chemistry
Photochemistry
01 natural sciences
Biochemistry
Fluorescence
Photoinduced electron transfer
chemistry.chemical_compound
Stilbenes
Humans
Aggregation-induced emission
Fluorescent Dyes
Quenching (fluorescence)
010405 organic chemistry
Organic Chemistry
General Chemistry
Hydrogen-Ion Concentration
0104 chemical sciences
chemistry
Molecular Probes
Intramolecular force
Molecular probe
Subjects
Details
- ISSN :
- 18614728
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Chemistry - An Asian Journal
- Accession number :
- edsair.doi.dedup.....5d0893b9cf20ae7856314f0a11df8568