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The invention of aldosterone, how the past resurfaces in pediatric endocrinology
- Source :
- Molecular and Cellular Endocrinology, Molecular and Cellular Endocrinology, Elsevier, 2021, 535, pp.111375. ⟨10.1016/j.mce.2021.111375⟩, Molecular and Cellular Endocrinology, 2021, 535, pp.111375. ⟨10.1016/j.mce.2021.111375⟩
- Publication Year :
- 2021
-
Abstract
- International audience; Sodium and water homeostasis are drastically modified at birth, in mammals, by the transition from aquatic life to terrestrial life. Accumulating evidence during the past ten years underscores the central role for the mineralocorticoid signaling pathway, in the fine regulation of this equilibrium, at this critical period of development. Interestingly, regarding evolution, while the mineralocorticoid receptor is expressed in fish, the appearance of its related ligand, aldosterone, coincides with terrestrial life, as it is first detected in lungfish and amphibian. Thus, aldosterone is likely one of the main hormones regulating the transition from an aquatic environment to an air environment. This review will focus on the different actors of the mineralocorticoid signaling pathway from aldosterone secretion in the adrenal gland, to mineralocorticoid receptor expression in the kidney, summarizing their regulation and roles throughout fetal and neonatal development, in the light of evolution.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
medicine.drug_class
Mineralocorticoid receptor
[SDV]Life Sciences [q-bio]
030209 endocrinology & metabolism
Biology
Kidney
Biochemistry
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
Internal medicine
Adrenal Glands
medicine
Animals
Humans
Molecular Biology
Aldosterone
Adrenal gland
Neonates
Gene Expression Regulation, Developmental
Amphibian
[SDV] Life Sciences [q-bio]
Fish
030104 developmental biology
medicine.anatomical_structure
Receptors, Mineralocorticoid
chemistry
Mineralocorticoid
Signal transduction
Homeostasis
Human
Hormone
Signal Transduction
Subjects
Details
- ISSN :
- 18728057 and 03037207
- Volume :
- 535
- Database :
- OpenAIRE
- Journal :
- Molecular and cellular endocrinology
- Accession number :
- edsair.doi.dedup.....5ce39196a7efedb5ef18f816fdc8c41f