Back to Search
Start Over
Synthesis of Poly(Ethylene Brassylate-Co-squaric Acid) as Potential Essential Oil Carrier
- Source :
- Pharmaceutics, Volume 13, Issue 4, Pharmaceutics, Vol 13, Iss 477, p 477 (2021)
- Publication Year :
- 2021
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2021.
-
Abstract
- Bio-based compounds are a leading direction in the context of the increased demand for these materials due to the numerous advantages associated with their use over conventional materials, which hardly degrade in the environment. At the same time, the use of essential oils and their components is generated mainly by finding alternative solutions to antibiotics and synthetic preservatives due to their bioactive characteristics, but also to their synergistic capacity during the manifestation of different biological properties. The present study is devoted to poly(ethylene brassylate-co-squaric acid) (PEBSA), synthesis and its use for thymol encapsulation and antibacterial system formation. The synthesized copolymer, performed through ethylene brassylate macrolactone ring-opening and copolymerization with squaric acid, was physicochemical characterized. Its amphiphilic character allowed the entrapment of thymol (Ty), a natural monoterpenoid phenol found in oil of thyme, a compound with strong antiseptic properties. The copolymer chemical structure was confirmed by spectroscopic analyses. Thermal analysis evidenced a good thermal stability for the copolymer. Additionally, the antimicrobial activity of PEBSA_Ty complex was investigated against eight different reference strains namely: bacterial strains—Staphylococcus aureus ATCC25923, Escherichia coli ATCC25922, Enterococcus faecalis ATCC 29212, Klebsiella pneumonie ATCC 10031 and Salmonella typhimurium ATCC 14028, yeast strains represented by Candida albicans ATCC10231 and Candida glabrata ATCC 2001, and the fungal strain Aspergillus brasiliensis ATCC9642.
- Subjects :
- Ethylene
Chemical structure
Pharmaceutical Science
lcsh:RS1-441
Context (language use)
02 engineering and technology
010402 general chemistry
medicine.disease_cause
01 natural sciences
Article
law.invention
lcsh:Pharmacy and materia medica
chemistry.chemical_compound
law
thymol
medicine
Organic chemistry
Thymol
Escherichia coli
Essential oil
squaric acid
antimicrobial activity
Candida glabrata
biology
bio-based copolymers
ring-opening copolymerization
021001 nanoscience & nanotechnology
Antimicrobial
biology.organism_classification
0104 chemical sciences
chemistry
ethylene brassylate
0210 nano-technology
Subjects
Details
- Language :
- English
- ISSN :
- 19994923
- Database :
- OpenAIRE
- Journal :
- Pharmaceutics
- Accession number :
- edsair.doi.dedup.....5ce254ac9567c61b0d88389d50f05a57
- Full Text :
- https://doi.org/10.3390/pharmaceutics13040477