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Effect of the mitochondrial antioxidant, Mito Vitamin E, on hypoxic-ischemic striatal injury in neonatal rats: a dose-response and stereological study
- Source :
- Experimental neurology. 199(2)
- Publication Year :
- 2005
-
Abstract
- A mitochondria-targeted antioxidant, Mito Vitamin E (MitoVit E), has previously been shown to prevent mitochondrial oxidative damage. The aim of this study was to investigate the effect of MitoVit E on neuronal survival in the rat striatum after acute perinatal hypoxia-ischemia. Continuous striatal infusion with 4.35 microM, 43.5 microM, or 148 microM of MitoVit E before, during, and after hypoxia-ischemia was not neuroprotective for striatal medium-spiny neurons. Pre- or posttreatment with 435 microM MitoVit E was neurotoxic. These results suggest that MitoVit E is not significantly neuroprotective for striatal medium-spiny neurons after acute perinatal hypoxic-ischemic brain injury. The results also suggest that mitochondrial oxidative damage does not contribute significantly to the death of striatal medium-spiny neurons after perinatal hypoxia-ischemia.
- Subjects :
- Male
medicine.medical_treatment
Ischemia
Striatum
Pharmacology
Mitochondrion
Biology
Medium spiny neuron
Neuroprotection
Antioxidants
Rats, Sprague-Dawley
Stereotaxic Techniques
Developmental Neuroscience
Pregnancy
medicine
Animals
Vitamin E
Dose-Response Relationship, Drug
medicine.disease
Corpus Striatum
Rats
medicine.anatomical_structure
nervous system
Neurology
Animals, Newborn
Stereotaxic technique
Hypoxia-Ischemia, Brain
Female
Neuron
Neuroscience
Subjects
Details
- ISSN :
- 00144886
- Volume :
- 199
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Experimental neurology
- Accession number :
- edsair.doi.dedup.....5cd970329a85e716d803065c7376f0ec