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Study of Adsorption and Desorption Performances of Zr-Based Metal–Organic Frameworks Using Paper Spray Mass Spectrometry
- Source :
- Materials, Materials; Volume 10; Issue 7; Pages: 769, Materials, Vol 10, Iss 7, p 769 (2017)
- Publication Year :
- 2017
- Publisher :
- MDPI AG, 2017.
-
Abstract
- The dynamic pore systems and high surface areas of flexible metal–organic framework materials make them excellent candidates to be used in different kinds of adsorption processes. However, the adsorption and desorption behaviors of therapeutic drugs on metal–organic frameworks in solution are not fully developed. Here, we systematically investigated the adsorption and desorption behaviors of a typical therapeutic drug, verapamil, over several Zr-based metal–organic frameworks [e.g., Zr-FUM, UiO-66(Zr), UiO-66(Zr)-NH2 and UiO-66(Zr)-2COOH] as well as ZrO2 in an acetonitrile solution by using paper spray mass spectrometry. In contrast to other materials, UiO-66(Zr)-2COOH demonstrated a superior adsorption performance to verapamil due to their strong acid-base and/or hydrogen-bond interactions, and the adsorption process fitted well with the pseudo-second-order kinetic model. As verapamil-adsorbed materials were used for desorption experiments, ZrO2 demonstrated the most favorable desorption performance, whereas UiO-66(Zr)-2COOH yielded the poorest desorption capability. These Zr-based materials had also been coated at the surface with filter papers for the analysis of various drugs and proteins in the process of paper spray mass spectrometry. The results demonstrated that among the studied materials, ZrO2-coated paper gave the most favorable desorption performance as a pure drug solution, whereas the paper from UiO-66(Zr) demonstrated the optimal capability in the analyses of therapeutic drugs in a complex matrix (e.g., blood) and a protein (e.g., myoglobin).
- Subjects :
- adsorption and desorption
Zr-based material
paper spray mass spectrometry
Materials science
Analytical chemistry
02 engineering and technology
010402 general chemistry
Mass spectrometry
lcsh:Technology
01 natural sciences
Article
chemistry.chemical_compound
Adsorption
Desorption
General Materials Science
lcsh:Microscopy
Acetonitrile
lcsh:QC120-168.85
lcsh:QH201-278.5
Kinetic model
lcsh:T
021001 nanoscience & nanotechnology
0104 chemical sciences
Fully developed
High surface
chemistry
Chemical engineering
lcsh:TA1-2040
lcsh:Descriptive and experimental mechanics
Metal-organic framework
lcsh:Electrical engineering. Electronics. Nuclear engineering
lcsh:Engineering (General). Civil engineering (General)
0210 nano-technology
lcsh:TK1-9971
Subjects
Details
- ISSN :
- 19961944
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Materials
- Accession number :
- edsair.doi.dedup.....5ccb19b762879e901968a5ffa27a7b16