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Quinpramine is a novel compound effective in ameliorating brain autoimmune disease
- Source :
- Experimental Neurology. 215:397-400
- Publication Year :
- 2009
- Publisher :
- Elsevier BV, 2009.
-
Abstract
- Acridine-iminodibenzyl chimeric compounds were previously introduced as a class of cholesterol-redistributing substances with antiprion effects. Here, we show that administration of the lead compound quinpramine to mice with experimental autoimmune encephalitis, an animal model of multiple sclerosis (MS), significantly ameliorates disease in preventive and therapeutic paradigms. Quinpramine treatment decreased the number of inflammatory CNS lesions, antigen-specific T-cell proliferation, and pro-inflammatory cytokines IFNgamma and IL-17. Quinpramine is thus an immunoregulatory drug that is a candidate pharmaceutical for MS.
- Subjects :
- Drug
Encephalomyelitis, Autoimmune, Experimental
T-Lymphocytes
media_common.quotation_subject
Disease
Central nervous system disease
Mice
Developmental Neuroscience
Immunopathology
medicine
Animals
Quinpramine
Cell Proliferation
Glycoproteins
media_common
Autoimmune disease
Autoimmune encephalitis
business.industry
Quinolinium Compounds
Multiple sclerosis
medicine.disease
Peptide Fragments
Mice, Inbred C57BL
Disease Models, Animal
Neurology
Immunology
Cytokines
Female
Myelin-Oligodendrocyte Glycoprotein
business
Subjects
Details
- ISSN :
- 00144886
- Volume :
- 215
- Database :
- OpenAIRE
- Journal :
- Experimental Neurology
- Accession number :
- edsair.doi.dedup.....5c9fe11029c473ec7862bda50b1357f8