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Respiratory outcomes of metformin use in patients with type 2 diabetes and chronic obstructive pulmonary disease
- Source :
- Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020), Scientific Reports
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Few studies investigated the respiratory outcomes of metformin use in patients with coexistent type 2 diabetes mellitus (T2DM) and chronic obstructive pulmonary disease (COPD). We want to compare the long-term respiratory endpoints of metformin use and nonuse in patients with T2DM and COPD. This retrospective cohort study enrolled patients with T2DM and COPD from Taiwan’s National Health Insurance Program between January 1, 2000, and December 31, 2012. Main outcomes were hospitalized bacterial pneumonia, hospitalization for COPD, noninvasive positive pressure ventilation (NIPPV), invasive mechanical ventilation (IMV), and lung cancer. In total, 20,644 propensity score-matched metformin users and nonusers were assessed. The adjusted hazard ratios (95% confidence intervals) of metformin use relative to nonuse for bacterial pneumonia, hospitalization for COPD, NIPPV, IMV, and lung cancer were 1.17 (1.11–1.23), 1.34 (1.26–1.43), 0.99 (0.89–1.10), 1.10 (1.03–1.17), and 1.12 (0.96–1.30). Metformin use also exhibited significant dose–response relationship with respect to the risks of bacterial pneumonia, hospitalization for COPD and IMV. Consistent results were found in the sensitivity test. This nationwide cohort study demonstrated that in patients with T2DM and COPD, metformin use was associated with higher risks of pneumonia, hospitalization for COPD, and IMV. If patients with COPD use metformin, vigilance with regard to their pulmonary condition may be required.
- Subjects :
- Male
Lung Neoplasms
endocrine system diseases
medicine.medical_treatment
lcsh:Medicine
Diseases
Type 2 diabetes
Pulmonary Disease, Chronic Obstructive
Endocrinology
0302 clinical medicine
Risk Factors
Longitudinal Studies
030212 general & internal medicine
lcsh:Science
COPD
Multidisciplinary
Hazard ratio
Middle Aged
Metformin
Hospitalization
Female
medicine.drug
Cohort study
Adult
medicine.medical_specialty
Taiwan
Article
03 medical and health sciences
Medical research
Internal medicine
Pneumonia, Bacterial
medicine
Humans
Hypoglycemic Agents
Aged
Retrospective Studies
Mechanical ventilation
business.industry
lcsh:R
Health care
Bacterial pneumonia
nutritional and metabolic diseases
Retrospective cohort study
medicine.disease
Respiration, Artificial
respiratory tract diseases
Diabetes Mellitus, Type 2
030228 respiratory system
lcsh:Q
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....5c94db835088da830a9123621c759e2c