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Factors associated with baseline and serial changes in circulating NT-proBNP and high-sensitivity cardiac troponin T in a population-based cohort (Dallas Heart Study)
- Source :
- Biomark Med
- Publication Year :
- 2021
- Publisher :
- Future Medicine Ltd, 2021.
-
Abstract
- Aim: N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin T (hs-cTnT) associate with structural heart disease and heart failure risk in individuals without known cardiovascular disease (CVD). However, few data are available regarding whether factors influencing levels of these two biomarkers are similar or distinct. We performed serial measurement of NT-proBNP and hs-cTnT in a contemporary multiethnic cohort with extensive phenotyping, with the goal of identifying their respective biological determinants in a population without known or suspected CVD. Methods: We evaluated 1877 participants of the Dallas Heart Study who had NT-proBNP and hs-cTnT measured and were free from clinical CVD at the each of its two examinations (2000–2002 and 2007–2009). Variables collected included demographic and risk factors, high-sensitivity C-reactive protein, body composition via dual-energy x-ray absorptiometry, coronary artery calcium by computed tomography, and cardiac dimensions and function by cardiac MRI. Linear regression was used to identify associations of these factors with each biomarker at baseline and with changes in biomarkers over follow-up. Results: NT-proBNP and hs-cTnT were poorly correlated at baseline (Spearman rho 0.083, p = 0.015), with only moderate correlation between change values (rho 0.18, p
- Subjects :
- Adult
Male
medicine.medical_specialty
Heart disease
medicine.drug_class
Clinical Biochemistry
Population
Disease
Correlation
Troponin T
Risk Factors
Internal medicine
Drug Discovery
Natriuretic Peptide, Brain
medicine
Natriuretic peptide
Humans
cardiovascular diseases
education
Aged
Heart Failure
education.field_of_study
business.industry
Biochemistry (medical)
Middle Aged
medicine.disease
Pathophysiology
Peptide Fragments
Heart failure
Cardiology
Biomarker (medicine)
Female
business
hormones, hormone substitutes, and hormone antagonists
Biomarkers
Research Article
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Biomark Med
- Accession number :
- edsair.doi.dedup.....5c90ad87eff43b6824ac752873e8a029