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Effect of Infant and Maternal Secretor Status on Rotavirus Vaccine Take—An Overview
- Source :
- Viruses, Viruses, Vol 13, Iss 1144, p 1144 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI, 2021.
-
Abstract
- Histo-blood group antigens, which are present on gut epithelial surfaces, function as receptors or attachment factors and mediate susceptibility to rotavirus infection. The major determinant for susceptibility is a functional FUT2 enzyme which mediates the presence of alpha-1,2 fucosylated blood group antigens in mucosa and secretions, yielding the secretor-positive phenotype. Secretors are more susceptible to infection with predominant rotavirus genotypes, as well as to the commonly used live rotavirus vaccines. Difference in susceptibility to the vaccines is one proposed factor for the varying degree of efficacy observed between countries. Besides infection susceptibility, secretor status has been found to modulate rotavirus specific antibody levels in adults, as well as composition of breastmilk in mothers and microbiota of the infant, which are other proposed factors affecting rotavirus vaccine take. Here, the known and possible effects of secretor status in both infant and mother on rotavirus vaccine take are reviewed and discussed. Funding Agencies|Swedish Research CouncilSwedish Research CouncilEuropean Commission [2018-02862]
- Subjects :
- 0301 basic medicine
Genotype
rotavirus
secretor status
vaccine take
mother
infant
030106 microbiology
Mothers
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Review
Biology
Antibodies, Viral
medicine.disease_cause
Microbiology
Rotavirus Infections
Blood group antigens
03 medical and health sciences
fluids and secretions
Antigen
Virology
Rotavirus
medicine
Humans
Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)
Rotavirus Vaccines
Fucosyltransferases
Phenotype
Rotavirus vaccine
QR1-502
Rotavirus infection
Specific antibody
030104 developmental biology
Infectious Diseases
Immunology
Blood Group Antigens
Female
Subjects
Details
- Language :
- English
- ISSN :
- 19994915
- Volume :
- 13
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Viruses
- Accession number :
- edsair.doi.dedup.....5c88a7007f9aacacf36ffafcdf3cbebf