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Epithelial cell cluster size affects force distribution in response to EGF-induced collective contractility
- Source :
- European Journal of Cell Biology : EJCB
- Publication Year :
- 2022
-
Abstract
- Several factors present in the extracellular environment regulate epithelial cell adhesion and dynamics. Among them, growth factors such as EGF, upon binding to their receptors at the cell surface, get internalized and directly activate the acto-myosin machinery. In this study we present the effects of EGF on the contractility of epithelial cancer cell colonies in confined geometry of different sizes. We show that the extent to which EGF triggers contractility scales with the cluster size and thus the number of cells. Moreover, the collective contractility results in a radial distribution of traction forces, which are dependent on integrin β1 peripheral adhesions and transmitted to neighboring cells through adherens junctions. Taken together, EGF-induced contractility acts on the mechanical crosstalk and linkage between the cell-cell and cell-matrix compartments, regulating collective responses.
- Subjects :
- Cèl·lules epitelials
Interacció cel·lular
Cancer cells
Histology
Cèl·lules
Cells
Epidermal growth factor
Proteins
Epithelial cells
Cell Biology
General Medicine
Pathology and Forensic Medicine
Contracció muscular
Muscle contraction
Cell interaction
Cèl·lules canceroses
Factor de creixement epidèrmic
Proteïnes
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- European Journal of Cell Biology : EJCB
- Accession number :
- edsair.doi.dedup.....5c8235700e4e16a836eb5da4c6aced17