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Central nervous system disease and genital disease in harbor porpoises (Phocoena phocoena) are associated with different herpesviruses
- Source :
- Veterinary Research, Veterinary Research, 47:28. BioMed Central Ltd., Veterinary Research, BioMed Central, 2016, 47 (1), pp.28. ⟨10.1186/s13567-016-0310-8⟩
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- International audience; AbstractHerpesvirus infection causes disease of variable severity in many species, including cetaceans. However, little is known about herpesvirus infection in harbor porpoises (Phocoena phocoena), despite being widespread in temperate coastal waters of the Northern Hemisphere. Therefore, we examined harbor porpoises that stranded alive in the Netherlands, Belgium, and Germany between 2000 and 2014 for herpesvirus infection and associated disease. Porpoises that died or had to be euthanized were autopsied, and samples were collected for virological and pathological analyses. We found one known herpesvirus (Phocoena phocoena herpesvirus type 1, PPHV-1)—a gammaherpesvirus—and two novel herpesviruses (PPHV-2 and PPHV-3)—both alphaherpesviruses—in these porpoises. A genital plaque, in which PPHV-1 was detected, occurred in 1% (1/117) of porpoises. The plaque was characterized by epithelial hyperplasia and intranuclear inclusion bodies that contained herpesvirus-like particles, and that stained positive by a PPHV-1-specific in situ hybridization test. PPHV-2 occurred in the brain of 2% (1/74) of porpoises. This infection was associated with lymphocytic encephalitis, characterized by neuronal necrosis and intranuclear inclusion bodies containing herpesvirus-like particles. PPHV-3 had a prevalence of 5% (4/74) in brain tissue, 5% (2/43) in blowhole swabs, and 2% (1/43) in genital swabs, but was not associated with disease. Phylogenetically, PPHV-1 was identical to a previously reported herpesvirus from a harbor porpoise, PPHV-2 showed closest identity with two herpesviruses from dolphins, and PPHV-3 showed closest identity with a cervid herpesvirus. In conclusion, harbor porpoises may be infected with at least three different herpesviruses, one of which can cause clinically severe neurological disease.
- Subjects :
- Male
0301 basic medicine
Pathology
medicine.medical_specialty
040301 veterinary sciences
[SDV]Life Sciences [q-bio]
viruses
Molecular Sequence Data
Phocoena
medicine.disease_cause
Herpesviridae
0403 veterinary science
Central nervous system disease
Viral Proteins
03 medical and health sciences
Belgium
Central Nervous System Diseases
Germany
biology.animal
medicine
Animals
Sex organ
14. Life underwater
Phylogeny
Netherlands
General Veterinary
biology
Viral culture
virus diseases
Herpesviridae Infections
Sequence Analysis, DNA
04 agricultural and veterinary sciences
medicine.disease
biology.organism_classification
Bottlenose dolphin
veterinary(all)
Virology
3. Good health
030104 developmental biology
Female
Genital Diseases, Male
Genital Diseases, Female
Porpoise
Encephalitis
Research Article
Subjects
Details
- ISSN :
- 12979716 and 09284249
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Veterinary Research
- Accession number :
- edsair.doi.dedup.....5c7ed50e540488cc1fb78d745e534ffd