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FcRL3 gene promoter variant is associated with peripheral arthritis in Crohn's disease
- Source :
- Inflammatory bowel diseases. 15(9)
- Publication Year :
- 2009
-
Abstract
- Background: The mechanisms responsible for the pathogenesis of peripheral arthropathies (PA) in Crohn's disease (CD) are largely unknown, although many studies indicate that genetic and environmental factors are likely to contribute to risk. Methods: Because variants in the Fc receptor-like 3 (FcRL3) gene have recently been associated with rheumatoid arthritis and several other autoimmune diseases, we tested 2 FcRL3 promoter variants (−169 C>T and −110 G>A) for association with PA in Spanish CD patients that were recruited from a single center and followed for at least 4 years (mean follow-up time, 11 years). Results: Among the 342 CD patients evaluated, there were 88 cases of peripheral arthropathy; 31 were classified as arthritis and 57 were classified as arthralgia. We used contingency tables and logistic regression to test for association between PA or either subtype and FcRL3 and other factors that have previously been associated with extraintestinal manifestations in CD. Conclusions: We found that female sex, colonic involvement, and the AA genotype at −110 G>A were associated with increased risk of both subtypes of PA, although the association appears to be stronger for arthritis than for arthralgia. (Inflamm Bowel Dis 2009)
- Subjects :
- Adult
Male
Adolescent
Arthritis
Disease
Inflammatory bowel disease
Polymorphism, Single Nucleotide
Pathogenesis
Young Adult
Crohn Disease
Risk Factors
Arthropathy
Genotype
medicine
Immunology and Allergy
Humans
Receptors, Immunologic
Child
Promoter Regions, Genetic
Aged
Aged, 80 and over
Crohn's disease
business.industry
Gastroenterology
Middle Aged
medicine.disease
Rheumatoid arthritis
Immunology
Female
business
Subjects
Details
- ISSN :
- 15364844
- Volume :
- 15
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Inflammatory bowel diseases
- Accession number :
- edsair.doi.dedup.....5c7ac9a7c7a09d19f18d13c89f07b989