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Primary Spinal Cord Glioblastoma Multiforme: A Retrospective Study of Patients at a Single Institution
- Source :
- World neurosurgery. 106
- Publication Year :
- 2016
-
Abstract
- Background and Objective Primary spinal cord (PSC) glioblastoma multiforme (GBM) is extremely rare and accounts for only 1.5% of all spinal cord tumors. Therefore, its treatment is still ill defined. To elucidate prognostic factors, we performed a single-institutional retrospective review of the largest series to date of patients with PSC GBM who underwent surgical resection in West China Hospital between 2008 and 2014. A total of 14 patients with PSC GBM were reviewed. Methods Demographic, operative, and postoperative factors were recorded. Overall survival (OS) and progression-free survival (PFS) were calculated and compared with the Kaplan-Meier method. Results Eight males (57%) and 6 females (43%) were involved in the study. Their median age was 28 years (range, 14–56 years). Median Karnofsky Performance Status score was 60 (range, 20–90). Four patients (28.6%) received gross total resection, 5 (35.7%) partial resection, and the remaining 5 (35.7%) biopsy only. Nine patients (64.3%) received postoperative radiotherapy and chemotherapy, 3 (21.4%) chemotherapy only, and 2 (14.3%) neither. Median follow-up period was 15 months (range, 5–26 months). One-year and 2-year survival was 78.5% (11/14) and 7.1% (1/14), respectively. Median OS was 15 months, and median PFS 8 months. Univariate log-rank analysis showed that OS and PFS were significantly associated with patients' age (P = 0.007 and P = 0.04, respectively) and postoperative radiotherapy (P = 0.001 and P = 0.002, respectively). However, preoperative Karnofsky Performance Status score affected only OS and did not affect PFS (P = 0.033 and P = 0.106, respectively). Conclusions According to our study, the combination of postoperative radiotherapy and temozolomide chemotherapy can improve prognosis and may serve as a feasible postoperative adjuvant treatment of PSC GBM.
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
medicine.medical_treatment
03 medical and health sciences
Young Adult
0302 clinical medicine
medicine
Temozolomide
Humans
Spinal Cord Neoplasms
Single institution
Karnofsky Performance Status
Antineoplastic Agents, Alkylating
Retrospective Studies
Chemotherapy
business.industry
Laminectomy
Retrospective cohort study
Partial resection
Middle Aged
medicine.disease
Spinal cord
Combined Modality Therapy
Surgery
Radiation therapy
Dacarbazine
medicine.anatomical_structure
Treatment Outcome
030220 oncology & carcinogenesis
Female
Neurology (clinical)
business
Glioblastoma
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- ISSN :
- 18788769
- Volume :
- 106
- Database :
- OpenAIRE
- Journal :
- World neurosurgery
- Accession number :
- edsair.doi.dedup.....5c7a9ef0bf40586cb4f5b68bf7021a7f