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NSG-Pro mouse model for uncovering resistance mechanisms and unique vulnerabilities in human luminal breast cancers

Authors :
Fransiscus E. Utama
Sameer S Udhane
Inna Chervoneva
Vindhya Udhane
Serge Y. Fuchs
Yunguang Sun
John F. Langenheim
Kay Uwe Wagner
Amy R. Peck
Julie M. Jorns
Alicia Yanac
Jess F. Peterson
Daniel Christ
Guanjun Xia
Hallgeir Rui
Michael J. Flister
Christopher J. Ormandy
Anne L. Rosenberg
Katherine Duffey
Shirng-Wern Tsaih
Romain Rouet
Marja T. Nevalainen
Ning Yang
Junling Zhang
Peter R. Schofield
Source :
Science Advances. 7
Publication Year :
2021
Publisher :
American Association for the Advancement of Science (AAAS), 2021.

Abstract

Most breast cancer deaths are caused by estrogen receptor-α–positive (ER+) disease. Preclinical progress is hampered by a shortage of therapy-naive ER+ tumor models that recapitulate metastatic pro...

Details

ISSN :
23752548
Volume :
7
Database :
OpenAIRE
Journal :
Science Advances
Accession number :
edsair.doi.dedup.....5c77199159be6ebf1eaef06514bb309e
Full Text :
https://doi.org/10.1126/sciadv.abc8145