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Rightward hemispheric asymmetries in auditory language cortex in children with autistic disorder: an MRI investigation
- Source :
- Journal of Neurodevelopmental Disorders, Gage, Nicole M.; Juranek, Jenifer; Filipek, Pauline A.; Osann, Kathryn; Flodman, Pamela; Isenberg, A. Lisette; et al.(2009). Rightward hemispheric asymmetries in auditory language cortex in children with autistic disorder: an MRI investigation. Journal of Neurodevelopmental Disorders: Advancing Interdisciplinary Research, 1(3), pp 205-214. doi: 10.1007/s11689-009-9010-2. Retrieved from: http://www.escholarship.org/uc/item/08x4283x
- Publication Year :
- 2009
-
Abstract
- Purpose: determine if language disorder in children with autistic disorder (AD) corresponds to abnormalities in hemispheric asymmetries in auditory language cortex. Methods: MRI morphometric study in children with AD (n = 50) to assess hemispheric asymmetries in auditory language cortex. A key region of interest was the planum temporale (PT), which is larger in the left hemisphere in most healthy individuals. Results: (i) Heschl’s gyrus and planum polare showed typical hemisphere asymmetry patterns; (ii) posterior Superior Temporal Gyrus (pSTG) showed significant rightward asymmetry; and (iii) PT showed a trend for rightward asymmetry that was significant when constrained to right-handed boys (n = 30). For right-handed boys, symmetry indices for pSTG were significantly positively correlated with those for PT. PT asymmetry was age dependent, with greater rightward asymmetry with age. Conclusions: results provide evidence for rightward asymmetry in auditory association areas (pSTG and PT) known to subserve language processing. Cumulatively, our data provide evidence for a differing maturational path for PT for lower functioning children with AD, with both pre- and post-natal experience likely playing a role in PT asymmetry. Electronic supplementary material The online version of this article (doi:10.1007/s11689-009-9010-2) contains supplementary material, which is available to authorized users.
- Subjects :
- medicine.medical_specialty
Cognitive Neuroscience
Planum temporale
Language cortex
Developmental disorder
Audiology
Auditory cortex
Pediatrics
Lateralization of brain function
Article
Posterior superior temporal gyrus
Pathology and Forensic Medicine
03 medical and health sciences
0302 clinical medicine
Neurobiology
Gyrus
Neuropsychology
Cortex (anatomy)
medicine
0501 psychology and cognitive sciences
Language disorder
Psychiatry
05 social sciences
Neurosciences
Human Genetics
medicine.disease
Heschl’s gyrus
Biomedicine
medicine.anatomical_structure
Pediatrics, Perinatology and Child Health
Neurology (clinical)
Psychology
Neuroscience
030217 neurology & neurosurgery
050104 developmental & child psychology
Subjects
Details
- ISSN :
- 18661955
- Volume :
- 1
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of neurodevelopmental disorders
- Accession number :
- edsair.doi.dedup.....5c748d7b1b1b92354b5c27673b305092
- Full Text :
- https://doi.org/10.1007/s11689-009-9010-2.