Back to Search
Start Over
Lymphoproliferation Impairment and Oxidative Stress in Blood Cells from Early Parkinson’s Disease Patients
- Source :
- E-Prints Complutense: Archivo Institucional de la UCM, Universidad Complutense de Madrid, International Journal of Molecular Sciences, E-Prints Complutense. Archivo Institucional de la UCM, instname, Volume 20, Issue 3, International Journal of Molecular Sciences, Vol 20, Iss 3, p 771 (2019)
- Publication Year :
- 2019
- Publisher :
- MDPI, 2019.
-
Abstract
- In Parkinson&rsquo<br />s Disease (PD), the peripheral changes in the functional capacity and redox state of immune cells has been scarcely investigated, especially in the early PD stages. Aging is a risk factor for PD, and the age-related impairment of the immune system, based on a chronic-oxidative stress situation, is involved in the rate of aging. We analyzed several functions in isolated peripheral blood neutrophils and mononuclear cells from PD stage 2 patients, and compared the results to those in healthy elderly and adult controls. Several oxidative stress and damage parameters were studied in whole blood cells. The results showed an impairment of the lymphoproliferative response in stimulated conditions in the PD patients compared with age-matched controls, who also showed typical immunosenescence in comparison with adult individuals. Higher oxidative stress and damage were observed in whole blood cells from PD patients (lower glutathione peroxidase activity, and higher oxidized glutathione and malondialdehyde contents). Our results suggest an accelerated immunosenescence in PD stage 2, and that several of the parameters studied could be appropriate peripheral biomarkers in the early stages of PD.
- Subjects :
- Male
0301 basic medicine
Parkinson's disease
lymphoproliferation
Neutrophils
immune functions
oxidative damage
medicine.disease_cause
lcsh:Chemistry
chemistry.chemical_compound
0302 clinical medicine
Malondialdehyde
oxidative stress
Lymphocytes
lcsh:QH301-705.5
Spectroscopy
Whole blood
immunosenescence
Parkinson Disease
General Medicine
Immunosenescence
Glutathione
Computer Science Applications
Female
Oxidation-Reduction
Adult
medicine.medical_specialty
Neurociencias
Peripheral blood mononuclear cell
Article
Catalysis
Parkinson’s Disease
Inorganic Chemistry
03 medical and health sciences
Immune system
Internal medicine
medicine
Humans
Physical and Theoretical Chemistry
Molecular Biology
Aged
Cell Proliferation
Glutathione Peroxidase
Blood Cells
Biología celular
business.industry
Organic Chemistry
biomarkers
medicine.disease
nervous system diseases
Cross-Sectional Studies
030104 developmental biology
Endocrinology
lcsh:Biology (General)
lcsh:QD1-999
chemistry
business
030217 neurology & neurosurgery
Lymphoproliferative response
Oxidative stress
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- E-Prints Complutense: Archivo Institucional de la UCM, Universidad Complutense de Madrid, International Journal of Molecular Sciences, E-Prints Complutense. Archivo Institucional de la UCM, instname, Volume 20, Issue 3, International Journal of Molecular Sciences, Vol 20, Iss 3, p 771 (2019)
- Accession number :
- edsair.doi.dedup.....5c6552964c824b4142e06156c3dff1da