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Identification of Two Distinct Mechanisms of Phagocytosis Controlled by Different Rho GTPases
- Source :
- Science. 282:1717-1721
- Publication Year :
- 1998
- Publisher :
- American Association for the Advancement of Science (AAAS), 1998.
-
Abstract
- The complement and immunoglobulin receptors are the major phagocytic receptors involved during infection. However, only immunoglobulin-dependent uptake results in a respiratory burst and an inflammatory response in macrophages. Rho guanosine triphosphatases (molecular switches that control the organization of the actin cytoskeleton) were found to be essential for both types of phagocytosis. Two distinct mechanisms of phagocytosis were identified: Type I, used by the immunoglobulin receptor, is mediated by Cdc42 and Rac, and type II, used by the complement receptor, is mediated by Rho. These results suggest a molecular basis for the different biological consequences that are associated with phagocytosis.
- Subjects :
- Phagocytic cup
Erythrocytes
Phagocytosis
Bacterial Toxins
Macrophage-1 Antigen
Cell Cycle Proteins
Complement receptor
CDC42
Biology
Transfection
Cell Line
GTP Phosphohydrolases
Mice
Bacterial Proteins
Antigens, CD
GTP-Binding Proteins
Phagosomes
Animals
Macrophage
cdc42 GTP-Binding Protein
Receptor
Multidisciplinary
Macrophages
Receptors, IgG
3T3 Cells
Opsonin Proteins
Actin cytoskeleton
Actins
rac GTP-Binding Proteins
Cell biology
Enzyme Activation
COS Cells
Immunology
Signal transduction
Subjects
Details
- ISSN :
- 10959203 and 00368075
- Volume :
- 282
- Database :
- OpenAIRE
- Journal :
- Science
- Accession number :
- edsair.doi.dedup.....5c6532575cab00aacae22b9d04a1d3ef