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A Randomized Controlled Trial of Compression Rates during Cardiopulmonary Resuscitation
- Source :
- Journal of Korean Medical Science
- Publication Year :
- 2016
- Publisher :
- The Korean Academy of Medical Sciences, 2016.
-
Abstract
- The objective of this study was to compare the efficacy of cardiopulmonary resuscitation (CPR) with 120 compressions per minute (CPM) to CPR with 100 CPM in patients with non-traumatic out-of-hospital cardiac arrest. We randomly assigned patients with non-traumatic out-of-hospital cardiac arrest into two groups upon arrival to the emergency department (ED). The patients received manual CPR either with 100 CPM (CPR-100 group) or 120 CPM (CPR-120 group). The primary outcome measure was sustained restoration of spontaneous circulation (ROSC). The secondary outcome measures were survival discharge from the hospital, one-month survival, and one-month survival with good functional status. Of 470 patients with cardiac arrest, 136 patients in the CPR-100 group and 156 patients in the CPR-120 group were included in the final analysis. A total of 69 patients (50.7%) in the CPR-100 group and 67 patients (42.9%) in the CPR-120 group had ROSC (absolute difference, 7.8% points; 95% confidence interval [CI], -3.7 to 19.2%; P = 0.183). The rates of survival discharge from the hospital, one-month survival, and one-month survival with good functional status were not different between the two groups (16.9% vs. 12.8%, P = 0.325; 12.5% vs. 6.4%, P = 0.073; 5.9% vs. 2.6%, P = 0.154, respectively). We did not find differences in the resuscitation outcomes between those who received CPR with 100 CPM and those with 120 CPM. However, a large trial is warranted, with adequate power to confirm a statistically non-significant trend toward superiority of CPR with 100 CPM. (Clinical Trial Registration Information: www.cris.nih.go.kr, cris.nih.go.kr number, KCT0000231)<br />Graphical Abstract
- Subjects :
- medicine.medical_treatment
Treatment outcome
education
030204 cardiovascular system & hematology
Out of hospital cardiac arrest
law.invention
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
Sex factors
law
medicine
Emergency medical services
Cardiac Arrest
030212 general & internal medicine
Cardiopulmonary resuscitation
health care economics and organizations
Patient discharge
business.industry
virus diseases
Basic life support
General Medicine
medicine.disease
Emergency & Critical Care Medicine
eye diseases
Cardiopulmonary Resuscitation
Original Article
Medical emergency
Basic Life Support
business
Subjects
Details
- Language :
- English
- ISSN :
- 15986357 and 10118934
- Volume :
- 31
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Journal of Korean Medical Science
- Accession number :
- edsair.doi.dedup.....5c606aca685a0fc533542e14067cef70