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The role of natural biological macromolecules: Deoxyribonucleic and ribonucleic acids in the formulation of new stable charge transfer complexes of thiophene Schiff bases for various life applications
- Source :
- International Journal of Biological Macromolecules. 193:1572-1586
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- The ecofriendly cellulose and gelatin provided sustainable and abundant sugars: d-ribofuranose, and 2-Deoxy-ribofuranose (starting reactants for preparative synthetic green chemistry pathways of charge transfer complexes. The natural available sugars d-ribofuranose, and 2-Deoxy-ribofuranose were obtained from facile hydrolysis of cellulose and gelatin natural macromolecules. Successive, low cost and facile alkaline- and acid hydrolysis of Deoxyribonucleic acid (DNA, from gelatin animal source) and ribonucleic acid (RNA, from cellulose plant source) yield the simple sugars: d-ribofuranose and 2-Deoxy-ribofuranose. Eight optically and biologically active charge transfer complexes were prepared from the reaction of the above sugars efficiently intercalated with two new prepared thiophene Schiff Lewis (electron donors) bases: 2-((2Hydroxybenzylidene) amino)-4, 5, 6, 7-tetrahydrobenzo [b] thiophene-3-carbonitrile (D1, 2-((Furan-2ylmethylene) amino) 4,5,6,7 tetrahydrobenzo [b] thiophene-3-carbonitrile (D2). The chemical structures of these prepared Schiff bases were confirmed using the mass spectra. The successful intercalation of the sugar units with the Lewis bases was ascertained using powder x ray diffraction. The molecular structures of the reaction products were proposed based on FTIR, 1H NMR. The optical activity of charge transfer complexes were confirmed using UV-Vis. Absorption spectroscopy. The surface morphology, microstructures, and particle size of the donors and charge transfer complexes were determined using scanning electron microscopy (SEM). The Lewis bases (D1) and (D2) showed no antimicrobial activity, while their charge transfer complexes showed good antimicrobial activity, suggesting their pharmaceutical and medicinal applications due to the potent biological activity against wide spread microbial microorganisms of Gram positive and Gram positive bacteria as well as some fungal species.
- Subjects :
- Magnetic Resonance Spectroscopy
food.ingredient
Macromolecular Substances
Intercalation (chemistry)
Microbial Sensitivity Tests
Thiophenes
Biochemistry
Gelatin
chemistry.chemical_compound
Hydrolysis
food
Coordination Complexes
Structural Biology
Spectroscopy, Fourier Transform Infrared
Polymer chemistry
Thiophene
Lewis acids and bases
Cellulose
Furans
Molecular Biology
Schiff Bases
Biological Products
Bacteria
Molecular Structure
Fungi
DNA
General Medicine
Anti-Bacterial Agents
chemistry
RNA
Acid hydrolysis
Sugars
Macromolecule
Subjects
Details
- ISSN :
- 01418130
- Volume :
- 193
- Database :
- OpenAIRE
- Journal :
- International Journal of Biological Macromolecules
- Accession number :
- edsair.doi.dedup.....5c5b9597dbd355e74851921012ef995e