Back to Search
Start Over
Lower Choline and Myo-Inositol in Temporo-Parietal Cortex Is Associated With Apathy in Amnestic MCI
- Source :
- Frontiers in aging neuroscience, Frontiers in Aging Neuroscience, 10:106. Frontiers Media SA, Frontiers in Aging Neuroscience, Vol 10 (2018), Frontiers in Aging Neuroscience
- Publication Year :
- 2018
-
Abstract
- Apathy is a common symptom in patients with amnestic mild cognitive impairment (aMCI) and is associated with an increased risk of progression to Alzheimer's disease (AD). The neural substrates underlying apathy in aMCI may involve multiple brain regions, including the anterior cingulate cortex and the temporo-parietal region. Here we investigated neurometabolites in brain regions that may underlie apathy in aMCI patients using proton magnetic resonance spectroscopy (H-1-MRS). Twenty-eight aMCI patients with varying degrees of apathy and 20 matched controls underwent H-1-MRS. Spectra were acquired from single voxels in the posterior cingulate cortex (PCC), dorsal anterior cingulate cortex (DACC), right dorsolateral prefrontal cortex (DLPFC), and right temporoparietal cortex (TPC). Apathy was measured with the Apathy Evaluation Scale (AES). Spearman partial correlations between metabolite concentrations in each region and severity of apathy were determined. Additionally, analyses of covariance (ANCOVA) were performed to determine whether metabolite changes differed between patients with or without clinically-diagnosed apathy. The degree of apathy was found to be negatively correlated with choline and myo-inositol (mI) in the TPC. Additional exploratory analyses suggested that N-acetylaspartate (NAA)/mI ratio was reduced in aMCI without clinical apathy but not in aMCI with clinical apathy. In the DACC, glutamate and glutamine (Glx) levels tended to be higher in the aMCI with apathy group compared to controls and reduced in association with depression scores. In conclusion, apathy in aMCI patients was associated with neurometabolite changes indicative of altered membranal integrity and glial function in the right TPC. Findings also indicated that in a clinically-diagnosed aMCI cohort, apathy symptoms may be suggestive of neural changes that are distinct from aMCI without apathy.
- Subjects :
- amnestic MCI
MRS
Aging
medicine.medical_specialty
myo-inositol
Cognitive Neuroscience
temporo-parietal cortex
Posterior parietal cortex
apathy
behavioral disciplines and activities
lcsh:RC321-571
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
choline
Internal medicine
Cortex (anatomy)
mental disorders
medicine
Choline
Apathy
Inositol
goal-directed behavior
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
Anterior cingulate cortex
Depression (differential diagnoses)
Original Research
030214 geriatrics
business.industry
medicine.anatomical_structure
chemistry
Posterior cingulate
Cardiology
Human medicine
medicine.symptom
business
030217 neurology & neurosurgery
Neuroscience
Subjects
Details
- Language :
- English
- ISSN :
- 16634365
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Frontiers in Aging Neuroscience
- Accession number :
- edsair.doi.dedup.....5c5b6b43a0e61216a36125fd6f0bb878