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Elevated Cerebrospinal Fluid Neopterin Concentration Is Associated with Disease Severity in Acute Puumala Hantavirus Infection
- Source :
- Clinical and Developmental Immunology, Clinical and Developmental Immunology, Vol 2013 (2013)
- Publication Year :
- 2013
- Publisher :
- Hindawi Limited, 2013.
-
Abstract
- Nephropathia epidemica (NE) caused by Puumala hantavirus (PUUV) is the most common hemorrhagic fever with renal syndrome (HFRS) in Europe. The infection activates immunological mechanisms that contribute to the pathogenesis and characteristics of the illness. In this study we measured cerebrospinal fluid (CSF) neopterin concentration from 23 acute-phase NE patients. We collected data on kidney function, markers of tissue permeability, haemodynamic properties, blood cell count, length of hospitalisation, inflammatory parameters, and ophthalmological properties. The neopterin levels were elevated (>5.8 nmol/L) in 22 (96%) NE-patients (mean 45.8 nmol/L); these were especially high in patients with intrathecal PUUV-IgM production (mean 58.2 nmol/L,P=0.01) and those with elevated CSF protein concentrations (mean 63.6 nmol/L,P<0.05). We also observed a correlation between the neopterin and high plasma creatinine value (r=0.66,P=0.001), low blood thrombocyte count (r=-0.42,P<0.05), and markedly disturbed refractory properties of an eye (r=0.47,P<0.05). Length of hospitalisation correlated with the neopterin (r=0.42,P<0.05; male patientsr=0.69,P<0.01). Patients with signs of tissue oedema and increased permeability also had high neopterin concentrations. These results reinforce the view that PUUV-HFRS is a general infection that affects the central nervous system and the blood-brain barrier.
- Subjects :
- lcsh:Immunologic diseases. Allergy
Male
Article Subject
education
Immunology
Hemodynamics
Renal function
Neopterin
Puumala virus
Severity of Illness Index
Pathogenesis
Leukocyte Count
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Cerebrospinal fluid
INFLAMMATION
Nephropathia epidemica
medicine
Humans
Immunology and Allergy
030212 general & internal medicine
030304 developmental biology
0303 health sciences
Creatinine
biology
business.industry
CENTRAL-NERVOUS-SYSTEM
General Medicine
medicine.disease
biology.organism_classification
NEPHROPATHIA-EPIDEMICA
3. Good health
RENAL SYNDROME
HEMORRHAGIC-FEVER
chemistry
Hemorrhagic Fever with Renal Syndrome
Acute Disease
VIRUS
RNA
Female
3111 Biomedicine
lcsh:RC581-607
business
Biomarkers
Research Article
Subjects
Details
- ISSN :
- 17402530 and 17402522
- Volume :
- 2013
- Database :
- OpenAIRE
- Journal :
- Clinical and Developmental Immunology
- Accession number :
- edsair.doi.dedup.....5c5186ca82f26a93dc88f2c7c95233fc